Jiaye Liu, Tao Li, Li Zhang, Aiqiang Xu – 18 December 2018 – In actual clinical practice, infinite nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B virus (HBV) infection is unrealistic. The most commonly used endpoint is suppression of HBV DNA to undetectable levels with normalization of alanine aminotransferase. However, this criterion for cessation of treatment is associated with various incidences of virological and clinical relapse.

Samer Chehade, Paul C. Adams – 18 December 2018

Katalina Funke, Don C. Rockey – 18 December 2018

Carol J. Soroka, David N. Assis, Leina S. Alrabadi, Scott Roberts, Laura Cusack, Ariel B. Jaffe, James L. Boyer – 18 December 2018 – Primary sclerosing cholangitis (PSC) is a heterogeneous and progressive fibroinflammatory cholangiopathy with no known etiology or effective treatment. Studies of PSC are limited due to difficulty in accessing the cholangiocyte, the small percentage of these cells in the liver, instability of in vitro culture systems, and reliance on samples from end‐stage disease.

Xueliang Zuo, Zhiqiang Chen, Juan Cai, Wen Gao, Yao Zhang, Guoyong Han, Liyong Pu, Zhengshan Wu, Wei You, Jianjie Qin, Xinzheng Dai, Hongbing Shen, Jindao Wu, Xuehao Wang – 18 December 2018 – Serotonin and its receptors have been shown to play critical regulatory roles in cancer biology. Nevertheless, the contributions of 5‐hydroxytryptamine 1D (5‐HT1D), an indispensable member of the serotonergic system, to hepatocellular carcinoma (HCC) remain unknown. The present study demonstrated that the 5‐HT1D expression level was significantly up‐regulated in HCC tissues and cell lines.

Luca Maroni, Claudio Pinto, Debora Maria Giordano, Stefania Saccomanno, Jesus M. Banales, Daniele Spallacci, Maria Cristina Albertini, Fiorenza Orlando, Mauro Provinciali, Malgorzata Milkiewicz, Espen Melum, Ibone Labiano, Piotr Milkiewicz, Chiara Rychlicki, Luciano Trozzi, Marina Scarpelli, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni – 18 December 2018 – Disorders of the biliary tree develop and progress differently according to patient age. It is currently not known whether the aging process affects the response to injury of cholangiocytes.

Mar Riveiro‐Barciela, Merche Gironella, Alicia Senín, María‐Teresa Salcedo, Xavier Merino‐Casabiel, Lluis Castells, Rafael Esteban, Maria Buti, Fernando Martínez‐Valle – 18 December 2018

Katalina Funke, Don C. Rockey – 18 December 2018

Max F. Thijssen, Isabel M. A. Brüggenwirth, Andrew Gillooly, Anastasia Khvorova, Timothy F. Kowalik, Paulo N. Martins – 18 December 2018 – RNA interference (RNAi) is a natural process of posttranscriptional gene regulation that has raised a lot of attention culminating with the Nobel Prize in Medicine in 2006. RNAi‐based therapeutics have been tested in experimental transplantation to reduce ischemia/reperfusion injury (IRI) with success.

Roslin Y. Docta, Tiago Ferronha, Joseph P. Sanderson, Thomas Weissensteiner, George R. Pope, Alan D. Bennett, Nicholas J. Pumphrey, Zoltan Ferjentsik, Laura L. Quinn, Guy E. Wiedermann, Victoria E. Anderson, Manoj Saini, Miguel Maroto, Elliot Norry, Andrew B. Gerry – 18 December 2018 – Patients with hepatocellular carcinoma (HCC) have a poor prognosis and limited therapeutic options. Alpha‐fetoprotein (AFP) is often expressed at high levels in HCC and is an established clinical biomarker of the disease.