Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Caitlin J. VanLith, Rebekah M. Guthman, Clara T. Nicolas, Kari L. Allen, Yuanhang Liu, Jennifer A. Chilton, Zachariah P. Tritz, Scott L. Nyberg, Robert A. Kaiser, Joseph B. Lillegard, Raymond D. Hickey – 15 February 2019 – Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease.

Application of 3‐Dimensional Printing in Pediatric Living Donor Liver Transplantation: A Single‐Center Experience

Pusen Wang, Weitao Que, Mingman Zhang, Xiaoke Dai, Kanru Yu, Chunguang Wang, Zhihai Peng, Lin Zhong – 15 February 2019 – Three‐dimensional (3D) printing has been used to support organ transplantations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D‐printed liver models in pediatric living donor liver transplantation (LDLT). The 3D images were printed to touchable liver models with transparent liver parenchyma, specifically colored hepatic vessels, and biliary structures.

The Yield and Safety of Screening Colonoscopy in Patients Evaluated for Liver Transplantation

Rosalie C. Oey, Laurelle van Tilburg, Nicole S. Erler, Herold J. Metselaar, Manon C.W. Spaander, Henk R. van Buuren, Robert A. de Man – 14 February 2019 – Colorectal cancer (CRC) screening with colonoscopy is commonly used in patients who are candidates for liver transplantation. We initiated this study to define the risk‐benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre–liver transplantation screening between 2004 and 2017 was conducted.

Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury‐Induced Wnt/β‐Catenin Signaling

Ludan Zhao, Yinhua Jin, Katie Donahue, Margaret Tsui, Matt Fish, Catriona Y. Logan, Bruce Wang, Roel Nusse – 14 February 2019 – In the liver, Wnt/β‐catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis. We examined Wnt gene expression and signaling after injury, and we show by in situ hybridization that Wnts are activated by acute carbon tetrachloride (CCl4) toxicity. Following injury, peri‐injury hepatocytes become Wnt‐responsive, expressing the Wnt target gene axis inhibition protein 2 (Axin2).

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