Key risk factors for development of drug-induced liver injury (DILI), especially genetic factors like HLA associations, are the focus of this lecture. Speakers will explore other genetic risk factors that may contribute to DILI and discuss recent data showing how the non-HLA gene PTPN22 may contribute to DILI due to the use of a number of different drugs.
The annual Hans Popper Lecture clarifies exciting new findings on cellular renewal mechanisms in liver disease and liver cancer. A subset of hepatocytes with high levels of telomerase are distributed throughout the liver lobule, serving to renew the organ during homeostasis and in response to injury. Learn how genetic ablation of these hepatocytes results in scarring and defective regenrative responses.
HCV-infected organs are now being used for transplantation to HCV-uninfected recipients. This program will review existing data on both liver and non-liver transplantation from HCV-positive donors to HCV-negative recipients and key ethical and practical issues related to HCV-infected donor organs, including whether this should be done only in clinical trials or could be accepted as standard of care.
How can women with liver diseases or organ transplants have healthier pregnancies? Careful, multidisciplinary management is key. This session will provide key updates in this area, covering topics like contraception use and pregnancy management across a spectrum of liver diseases, including the liver transplant population.
Don’t overlook any of the groundbreaking basic science research presented at The Liver Meeting®. New this year, an expert will briefly review all the basic science abstracts presented at the meeting in one condensed session.
Discover how allocation impacts long-term outcomes for the transplant recipient and liver graft at this session. Speakers will address ways to improve the ability to interpret and identify the significance of long-term, post-transplant liver biopsy findings and offer tools to expand one’s perspective on individualizing immunosuppression to optimize long-term outcomes for the allograft and recipient.
Anoop N. Koshy, Omar Farouque, Paul Calafiore, Paul J. Gow – 11 November 2019
Manhal Izzy, Lisa B. VanWagner, Grace Lin, Mario Altieri, James Y. Findlay, Jae K. Oh, Kymberly Watt, Samuel S. Lee, the Cirrhotic Cardiomyopathy Consortium: The Cirrhotic Cardiomyopathy Consortium is a multidisciplinary international group whose focus is to improve the understanding of cirrhotic cardiomyopathy, its management and outcomes – 11 November 2019
Review data from ongoing clinical trials for alcoholic hepatitis, explore the role of early liver transplantation and discuss the management of alcohol use disorder in patients with alcoholic hepatitis and acute on chronic liver failure. Topics covered include trial design considering standards of care and liver transplantation’s emerging role and subject recruitment challenges for clinical trials in alcoholic hepatitis.
Acute on Chronic Liver Failure (ACLF) is a well-recognized rapid course of liver disease that can have devastating consequences on patients. At this symposium, faculty will discuss ACLF’s common triggers and explore current perspectives of management in the context of these triggering events. Topics covered include microbiome analysis to identify high-risk patients and the role of transplantation.