Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal–Regulating Kinase 1 Pathways

Zhen Huang, Lei‐Ming Wu, Jie‐Lei Zhang, Abdelkarim Sabri, Shou‐Jun Wang, Gui‐Jun Qin, Chang‐Qing Guo, Hong‐Tao Wen, Bin‐Bin Du, Dian‐Hong Zhang, Ling‐Yao Kong, Xin‐Yu Tian, Rui Yao, Ya‐Peng Li, Cui Liang, Peng‐Cheng Li, Zheng Wang, Jin‐Yan Guo, Ling Li, Jian‐Zeng Dong, Yan‐Zhou Zhang – 1 March 2019 – Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Due to the growing economic burden of NAFLD on public health, it has become an emergent target for clinical intervention.

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Jaclyn LoPiccolo, Michael I. Brener, Kiyoko Oshima, Evan J. Lipson, James P. Hamilton – 28 February 2019

The “Skinny” on Assessment and Utilization of Steatotic Liver Grafts: A Systematic Review

Kristopher P. Croome, David D. Lee, C. Burcin Taner – 28 February 2019 – The frequency at which steatotic deceased donor liver grafts are encountered will likely continue to increase. Utilization of liver grafts with moderate‐to‐severe steatosis for liver transplantation (LT) has been previously shown to be associated with increased rates of primary nonfunction and decreased recipient survival. In order to better inform clinical decision making and guide future research, critical evaluation of the literature on donor liver steatosis and posttransplantation outcome is needed.

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