The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials

Arun J. Sanyal, Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, Raul Aguilar Schall, Catherine Jia, Bryan McColgan, C. Stephen Djedjos, John G. McHutchison, G. Mani Subramanian, Robert P. Myers, Zobair Younossi, Andrew J. Muir, Nezam H. Afdhal, Jaime Bosch, Zachary Goodman – 16 April 2019 – Progression of nonalcoholic steatohepatitis (NASH) is incompletely characterized.

HDAC6 Suppresses Let‐7i‐5p to Elicit TSP1/CD47‐Mediated Anti‐Tumorigenesis and Phagocytosis of Hepatocellular Carcinoma

Hee Doo Yang, Hyung Seok Kim, Sang Yean Kim, Min Jeong Na, Gyeongdeok Yang, Jung Woo Eun, Hee Jung Wang, Jae Youn Cheong, Won Sang Park, Suk Woo Nam – 16 April 2019 – Histone deacetylase 6 (HDAC6) uniquely serves as a tumor suppressor in hepatocellular carcinogenesis, but the underlying mechanisms leading to tumor suppression are not fully understood. To identify comprehensive microRNAs (miRNAs) regulated by HDAC6 in hepatocellular carcinogenesis, differential miRNA expression analysis of HDAC6‐transfected Hep3B cells was performed.

Maternal Immunity Influences Vertical Transmission of Hepatitis B to Newborns

Ashish Kumar Vyas, Pooja Negi, Sharda Patra, Jaswinder Singh Maras, Gayatri Ramakrishna, Shiv Kumar Sarin, Nirupma Trehanpati – 16 April 2019 – Vertical transmission of hepatitis B virus (HBV) from the mother to the newborn often results in viral persistence. To understand mechanisms of maternofetal HBV transmission, we studied maternal immunity and peripheral blood mononuclear cell (PBMC) transcriptome in mothers and newborns.

Incorporating Weight Loss Medications Into Hepatology Practice for Nonalcoholic Steatohepatitis

Albert Do, Eric J. Kuszewski, Karl A. Langberg, Wajahat Z. Mehal – 16 April 2019 – There is an urgent need for practical approaches to patients with nonalcoholic steatohepatitis (NASH). Total body weight loss (TBWL) is an important approach, as its effects are amplified in the liver, with 10% TBWL resulting in a 50% loss of liver triglycerides and improvement in all aspects of NASH histology. Lifestyle changes are the first step in addressing TBWL, but uncommonly result in the range required to improve liver histology in NASH (7%‐10%).

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