Qing Li, Xiongxiong Pan, Deming Zhu, Zhengming Deng, Runqiu Jiang, Xuehao Wang – 20 April 2019 – Glucose metabolism reprogramming, which is a well‐established characteristic of multiple cancers, demands a higher rate of glycolysis to meet the increasing demands for macromolecular synthesis and to maintain rapid proliferation in a hypoxic environment. However, the mechanism underlying this switch remains to be elucidated. In this study, we investigated the function of circular RNA MAT2B (circMAT2B) in hepatocellular carcinoma (HCC) glucose metabolism reprogramming and malignancy.

Yan Xie, Hitoshi Matsumoto, Susan Kennedy, Elizabeth P. Newberry, William Moritz, Brian J. DeBosch, Kelle H. Moley, Deborah C. Rubin, Brad W. Warner, Andrew L. Kau, Phillip I. Tarr, Todd N. Wylie, Kristine M. Wylie, Nicholas O. Davidson – 20 April 2019 – The mechanisms by which alterations in intestinal bile acid (BA) metabolism improve systemic glucose tolerance and hepatic metabolic homeostasis are incompletely understood.

Yuanguo Wang, Kangsheng Tu, Donglian Liu, Luyang Guo, Yunru Chen, Qing Li, Jessica L. Maiers, Zhikui Liu, Vijay H. Shah, Changwei Dou, Daniel Tschumperlin, Luke Voneschen, Rendong Yang, Ningling Kang – 20 April 2019 – Nuclear translocation of mothers against decapentaplegic homolog 2/3 (SMAD2/3), core transcription factors of transforming growth factor β (TGF‐β) signaling, is critical for hepatic stellate cell (HSC) differentiation into metastasis‐promoting myofibroblasts.

Matthew J. Stotts, Opaku Adjapong, David E. Kaplan – 20 April 2019

Josh Levitsky, Sumeet K. Asrani, Michael Abecassis, Richard Ruiz, Linda W. Jennings, Goran Klintmalm – 19 April 2019 – In patients with end‐stage liver disease, the ability to predict recovery of renal function following liver transplantation (LT) remains elusive. However, several important clinical decisions depend on whether renal dysfunction is recoverable after LT.

Fabrizio Francesco, Duilio Pagano, Gennaro Martucci, Davide Cintorino, Salvatore Gruttadauria – 19 April 2019

Carina Hage, Sabine Hoves, Léanne Strauss, Stefan Bissinger, Ylva Prinz, Thomas Pöschinger, Fabian Kiessling, Carola H. Ries – 19 April 2019 – Antiangiogenic and cytotoxic effects are considered the principal mechanisms of action of sorafenib, a multitarget kinase inhibitor approved for the treatment of hepatocellular carcinoma (HCC). We report that sorafenib also acts through direct immune modulation, indispensable for its antitumor activity.

Llilda Barata, Mary F. Feitosa, Lawrence F. Bielak, Brian Halligan, Abigail S. Baldridge, Xiuqing Guo, Laura M. Yerges‐Armstrong, Albert V. Smith, Jie Yao, Nicholette D. Palmer, Lisa B. VanWagner, J. Jeffrey Carr, Yii‐Der I. Chen, Matthew Allison, Matthew J. Budoff, Samuel K. Handelman, Sharon L.R. Kardia, Thomas H. Mosley, Kathleen Ryan, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Jerome I. Rotter, Myriam Fornage, Laura J. Rasmussen‐Torvik, Ingrid B. Borecki, Jeffrey R. O’Connell, Patricia A. Peyser, Elizabeth K. Speliotes, Michael A.

Shikha S. Sundaram, Marzena Swiderska‐Syn, Ronald J. Sokol, Ann C. Halbower, Kelley E. Capocelli, Zhaoxing Pan, Kristen Robbins, Brian Graham, Anna Mae Diehl – 17 April 2019 – Chronic intermittent hypoxia and hedgehog (Hh) pathway dysregulation are associated with nonalcoholic fatty liver disease (NAFLD) progression. In this study, we determined the relationship between obstructive sleep apnea (OSA)/nocturnal hypoxia and Hh signaling in pediatric NAFLD.

17 April 2019