Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study

Binita M. Kamath, Wen Ye, Nathan P. Goodrich, Kathleen M. Loomes, Rene Romero, James E. Heubi, Daniel H. Leung, Nancy B. Spinner, David A. Piccoli, Estella M. Alonso, Stephen L. Guthery, Saul J. Karpen, Cara L. Mack, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, James E. Squires, Jeffrey Teckman, Kasper S. Wang, Richard Thompson, John C. Magee, Ronald J. Sokol, for the Childhood Liver Disease Research Network (ChiLDReN) – 22 January 2020 – Alagille syndrome (ALGS) is an autosomal dominant multisystem disorder with cholestasis as a defining clinical feature.

Deficits in Muscle Strength and Physical Performance Influence Physical Activity in Sarcopenic Children After Liver Transplantation

Poh Hwa Ooi, Vera C. Mazurak, Kerry Siminoski, Ravi Bhargava, Jason Y. K. Yap, Susan M. Gilmour, Diana R. Mager – 22 January 2020 – Sarcopenia is a muscle disease characterized by reduced skeletal muscle mass (SMM), muscle strength, and physical performance. Reduced SMM has been identified in children after liver transplantation (LT), but no information related to muscle strength/physical performance or lifestyle factors contributing to sarcopenia is available.

Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH

Rohit Loomba, Brent A Neuschwander‐Tetri, Arun Sanyal, Naga Chalasani, Anna Mae Diehl, Norah Terrault, Kris Kowdley, Srinivasan Dasarathy, David Kleiner, Cynthia Behling, Joel Lavine, Mark Van Natta, Michael Middleton, James Tonascia, Claude Sirlin, for the NASH Clinical Research Network – 21 January 2020

Hepatology Highlights

Pir A. Shah, Daryl T.Y. Lau, Nicholas W. Russo, Robert S. Brown, Jessica L. Maiers, Robert E. Schwartz, Norihiro Imai, Tibor I. Krisko, Amaia Navarro‐Corcuera, Nidhi Jalan‐Sakrikar, Joseph F. Pisa, Arun B. Jesudian, Zaid H. Tafesh, Brett E. Fortune, Enis Kostallari – 21 January 2020

Prognostic Factors in Pediatric Early Liver Retransplantation

Isabel Cañon Reyes, Esteban Halac, Diego Aredes, Leandro Lauferman, Guillermo Cervio, Marcelo Dip, Julia Minetto, Hayellen Reijenstein, Veronica Meza, Maria Gole, Agustina Jacobo Dillon, Oscar Imventarza – 21 January 2020 – The most common indications for early liver retransplantation (eRe‐LT) are vascular complications and primary nonfunction (PNF). These patients are usually in a critical clinical condition that can affect their chances of survival. In fact, the survival of these patients is usually lower compared with the patients undergoing a first transplant.

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