Impaired Bile Secretion Promotes Hepatobiliary Injury in Sickle Cell Disease

Ravi Vats, Silvia Liu, Junjie Zhu, Dhanunjay Mukhi, Egemen Tutuncuoglu, Nayra Cardenes, Sucha Singh, Tomasz Brzoska, Karis Kosar, Mikhil Bamne, Jude Jonassaint, Adeola Adebayo Michael, Simon C. Watkins, Cheryl Hillery, Xiaochao Ma, Kari Nejak‐Bowen, Mauricio Rojas, Mark T. Gladwin, Gregory J. Kato, Sadeesh Ramakrishnan, Prithu Sundd, Satdarshan Pal Monga, Tirthadipa Pradhan‐Sundd – 19 March 2020

Lipoprotein‐Like Nanoparticle Carrying Small Interfering RNA Against Spalt‐Like Transcription Factor 4 Effectively Targets Hepatocellular Carcinoma Cells and Decreases Tumor Burden

William Cruz, Huang Huang, Brian Barber, Elisa Pasini, Lili Ding, Gang Zheng, Juan Chen, Mamatha Bhat – 16 March 2020 – Patients with advanced hepatocellular carcinoma (HCC) are often unable to tolerate chemotherapy due to liver dysfunction in the setting of cirrhosis. We investigate high‐density lipoprotein (HDL)‐mimicking peptide phospholipid scaffold (HPPS), which are nanoparticles that capitalize on normal lipoprotein metabolism and transport, as a solution for directed delivery of small interfering RNA (siRNA) cargo into HCC cells.

Subscribe to