Mast Cells Induce Ductular Reaction Mimicking Liver Injury in Mice Through Mast Cell–Derived Transforming Growth Factor Beta 1 Signaling

Konstantina Kyritsi, Lindsey Kennedy, Vik Meadows, Laura Hargrove, Jennifer Demieville, Linh Pham, Amelia Sybenga, Debjyoti Kundu, Karla Cerritos, Fanyin Meng, Gianfranco Alpini, Heather Francis – 6 August 2020

Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease

Benjamin L. Shneider, Nathan P. Goodrich, Wen Ye, Cindy Sawyers, Jean P. Molleston, Robert M. Merion, Daniel H. Leung, Saul J. Karpen, Binita M. Kamath, Laurel Cavallo, Kasper Wang, Jeffrey H. Teckman, James E. Squires, Shikha S. Sundaram, Philip Rosenthal, Rene Romero, Karen F. Murray, Kathleen M. Loomes, M. Kyle Jensen, Jorge A. Bezerra, Lee M. Bass, Ronald J. Sokol, John C. Magee, For the Childhood Liver Disease Research Network (ChiLDReN) – 5 August 2020 – Elastographic measurement of liver stiffness is of growing importance in the assessment of liver disease.

A Circular RNA, Cholangiocarcinoma‐Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers

Yi Xu, Kaiming Leng, Yue Yao, Pengcheng Kang, Guanqun Liao, Yi Han, Guangjun Shi, Daolin Ji, Peng Huang, Wangyang Zheng, Zhenglong Li, Jinglin Li, Lining Huang, Liang Yu, Yongxu Zhou, Xingming Jiang, Hao Wang, Chunlong Li, Zhilei Su, Sheng Tai, Xiangyu Zhong, Zhidong Wang, Yunfu Cui – 4 August 2020

Differential Impact of Extended Criteria Donors After Brain Death or Circulatory Death in Adult Liver Transplantation

Keval Pandya, Vinay Sastry, Mara T. Panlilio, Terry C. F. Yip, Shirin Salimi, Claire West, Susan Virtue, Mark Wells, Michael Crawford, Carlo Pulitano, Simone I. Strasser, Geoffrey W. McCaughan, Avik Majumdar, Ken Liu – 4 August 2020 – Using grafts from extended criteria donors (ECDs) and donation after circulatory death (DCD) donors is a strategy to address organ shortage in liver transplantation (LT). We studied the characteristics and outcomes of ECD and DCD grafts. We retrospectively studied consecutive adults who underwent deceased donor LT between 2006 and 2019.

Functionally Diverse Inflammatory Responses in Peripheral and Liver Monocytes in Alcohol‐Associated Hepatitis

Adam Kim, Annette Bellar, Megan R. McMullen, Xiaoxia Li, Laura E. Nagy – 4 August 2020 – Alcohol‐associated hepatitis (AH) is an acute inflammatory disease in which gut‐microbial byproducts enter circulation and peripheral immune cells infiltrate the liver, leading to nonresolving inflammation and injury. Single‐cell RNA sequencing of peripheral blood mononuclear cells isolated from patients with AH and healthy controls paired with lipopolysaccharide (LPS) challenge revealed how diverse monocyte responses are divided among individual cells and change in disease.

Hepatocellular Carcinoma–Circulating Tumor Cells Expressing PD‐L1 Are Prognostic and Potentially Associated With Response to Checkpoint Inhibitors

Paul Winograd, Shuang Hou, Colin M. Court, Yi‐Te Lee, Pin‐Jung Chen, Yazhen Zhu, Saeed Sadeghi, Richard S. Finn, Pai‐Chi Teng, Jasmin J. Wang, Zhicheng Zhang, Hongtao Liu, Ronald W. Busuttil, James S Tomlinson, Hsian‐Rong Tseng, Vatche G. Agopian – 4 August 2020 – Hepatocellular carcinoma (HCC) is a leading cause of mortality. Checkpoint inhibitors of programmed cell death protein‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have shown great efficacy, but lack biomarkers that predict response.

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