Yes‐Associated Protein Is Crucial for Constitutive Androstane Receptor‐Driven Hepatocyte Proliferation But Not for Induction of Drug Metabolism Genes in Mice

Bharat Bhushan, Laura Molina, Kelly Koral, John W. Stoops, Wendy M. Mars, Swati Banerjee, Anne Orr, Shirish Paranjpe, Satdarshan P. Monga, Joseph Locker, George K. Michalopoulos – 13 August 2020

Activation of Liver X Receptor α Sensitizes Mice to T‐Cell Mediated Hepatitis

Li Gao, Bin Li, Jingyuan Wang, Danhua Shen, Min Yang, Runzi Sun, Hung‐Chun Tung, Meishu Xu, Songrong Ren, Min Zhang, Da Yang, Binfeng Lu, Hui Wang, Yulan Liu, Wen Xie – 12 August 2020 – Autoimmune hepatitis (AIH) is an inflammatory disease of the liver. Liver X receptors (LXRs), including the α and β isoforms, are previously known for their anti‐inflammatory activities. The goal of this study is to determine whether and how LXR plays a role in AIH.

Serum Sphingosine‐1‐Phosphate Is Decreased in Patients With Acute‐on‐Chronic Liver Failure and Predicts Early Mortality

Victoria T. Mücke, Katharina Maria Schwarzkopf, Dominique Thomas, Marcus M. Mücke, Sabrina Rüschenbaum, Jonel Trebicka, Josef Pfeilschifter, Stefan Zeuzem, Christian M. Lange, Georgios Grammatikos – 12 August 2020 – Sphingosine‐1‐phosphate (S1P) regulates pathophysiological processes, including liver regeneration, vascular tone control, and immune response. In patients with liver cirrhosis, acute deterioration of liver function is associated with high mortality rates.

Hepatocellular Carcinoma in Hispanic Patients: Trends and Outcomes in a Large United States Cohort

Sydney Pomenti, Cassandra Gandle, Hamzah Abu Sbeih, Meaghan Phipps, Alexandra Livanos, Averill Guo, Jonathan Yeh, Heather Burney, Hao Liu, Lara Dakhoul, Carla Kettler, Samer Gawrieh, Andrew deLemos, Andrew Scanga, Naga Chalasani, Ethan Miller, Julia Wattacheril – 12 August 2020 – Hepatocellular carcinoma (HCC) has a strong racial and ethnic association, with Hispanic patients having a higher incidence and mortality. However, there are limited data regarding clinical features and outcomes.

Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management

Sandy Feng, John C. Bucuvalas, George V. Mazariegos, John C. Magee, Alberto Sanchez‐Fueyo, Katharine M. Spain, Andrew Lesniak, Sai Kanaparthi, Emily Perito, Veena L. Venkat, Bryna E. Burrell, Estella M. Alonso, Nancy D. Bridges, Edward Doo, Nitika A. Gupta, Ryan W. Himes, David Ikle, Annette M. Jackson, Steven J. Lobritto, Juan Jose Lozano, Mercedes Martinez, Vicky L. Ng, Elizabeth B. Rand, Averell H. Sherker, Shikha S. Sundaram, Yumirle P. Turmelle, Michele Wood‐Trageser, Anthony J. Demetris – 12 August 2020

Sequential Protocol Biopsies Post–Liver Transplant From Donors With Moderate Macrosteatosis: What Happens to the Fat?

Kristopher P. Croome, David Livingston, Sarah Croome, Andrew P. Keaveny, C. Burcin Taner, Raouf Nakhleh – 11 August 2020 – The number of steatotic deceased donor livers encountered has continued to rise as a result of the obesity epidemic. Little is known about the histological characteristics of moderately macrosteatotic livers over time in the recipient following liver transplantation (LT). All recipients undergoing LT at Mayo Clinic Florida with donor livers with moderate macrosteatosis (30%‐60%) from 2000‐2017 were identified (n = 96).

Utility of Mac‐2 Binding Protein Glycosylation Isomer to Evaluate Graft Status After Liver Transplantation

Yusuke Kimura, Kojiro Taura, Nguyen Hai Nam, Yusuke Uemoto, Kenji Yoshino, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Kazutaka Tanabe, Yukinori Koyama, Takayuki Anazawa, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Naoko Kamo, Satoru Seo, Keiko Iwaisako, Koichiro Hata, Takumi Imai, Shinji Uemoto – 11 August 2020 – Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel liver fibrosis biomarker, but there are few studies on M2BPGi in liver transplantation (LT) recipients. This study aimed to evaluate the utility of M2BPGi measurement in LT recipients.

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