Human Leukocyte Antigen B*14:01 and B*35:01 Are Associated With Trimethoprim‐Sulfamethoxazole Induced Liver Injury

Yi‐Ju Li, Elizabeth J. Phillips, Andrew Dellinger, Paola Nicoletti, Ryan Schutte, Danmeng Li, David A. Ostrov, Robert J. Fontana, Paul B. Watkins, Andrew Stolz, Ann K Daly, Guruprasad P Aithal, Huiman Barnhart, Naga Chalasani, the Drug‐induced Liver Injury Network – 9 April 2020

Ritonavir and Lopinavir Suppress RCE1 and CAAX Rab Proteins Sensitizing the Liver to Organelle Stress and Injury

Atousa Khalatbari, Pratibha Mishra, Hui Han, Yuxin He, Michelle MacVeigh‐Aloni, Cheng Ji – 8 April 2020 – Organelle stress and Liver injuries often occur in human immunodeficiency virus (HIV) infected patients under anti‐HIV therapies, yet few molecular off‐targets of anti‐HIV drugs have been identified in the liver. Here, we found through total RNA sequencing that the transcription of a host protease Ras converting CAAX endopeptidase 1 (RCE1) was altered in HepG2 cells treated with anti‐HIV protease inhibitors, ritonavir and lopinavir.

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