Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis
Jaswinder Singh Maras, Sukanta Das, Adil Bhat, Ashish Kumar Vyas, Gaurav Yadav, Sudrishti Chaudhary, Sukriti Sukriti, Abhishak C. Gupta, Chagan Bihari, Rakhi Mahiwall, Shiv Kumar Sarin – 30 October 2019 – Severe alcoholic hepatitis (SAH) has high mortality. Dysregulated lipid transport and metabolism in liver/macrophages contributes to disease pathophysiology. Paraoxonase/arylesterase 1 (PON1), a liver‐specific enzyme, inhibits oxidation of phospholipids and prevents lipid‐mediated oxidative damage.