Frailty and the Burden of Concurrent and Incident Disability in Patients With Cirrhosis: A Prospective Cohort Study

Jennifer C. Lai, Jennifer L. Dodge, Charles E. McCulloch, Kenneth E. Covinsky, Jonathan P. Singer – 31 October 2019 – Frailty results from the chronic effects of malnutrition and muscle wasting in patients with cirrhosis. It is well‐established that frailty is strongly associated with mortality in this population. However, little is known of its relationship with physical disability, a critical patient‐centered outcome.

Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis

Jaswinder Singh Maras, Sukanta Das, Adil Bhat, Ashish Kumar Vyas, Gaurav Yadav, Sudrishti Chaudhary, Sukriti Sukriti, Abhishak C. Gupta, Chagan Bihari, Rakhi Mahiwall, Shiv Kumar Sarin – 30 October 2019 – Severe alcoholic hepatitis (SAH) has high mortality. Dysregulated lipid transport and metabolism in liver/macrophages contributes to disease pathophysiology. Paraoxonase/arylesterase 1 (PON1), a liver‐specific enzyme, inhibits oxidation of phospholipids and prevents lipid‐mediated oxidative damage.

Posttransplant Outcome of Lean Compared With Obese Nonalcoholic Steatohepatitis in the United States: The Obesity Paradox

Sanjaya K. Satapathy, Yu Jiang, Uchenna Agbim, Cen Wu, David E. Bernstein, Lewis W. Teperman, Satish K. Kedia, Guruprasad P. Aithal, Kalyan Ram Bhamidimarri, Ajay Duseja, Rakhi Maiwall, Benedict Maliakkal, Prasun Jalal, Keyur Patel, Puneet Puri, Ravi Ravinuthala, Vincent Wai‐Sun Wong, Manal F. Abdelmalek, Aijaz Ahmed, Paul J. Thuluvath, Ashwani K. Singal, for the Global NAFLD Consortium – 30 October 2019 – Morbid obesity is considered a relative contraindication for liver transplantation (LT).

Hepatology Highlights

Muhammad Amir, Ravi S. Vora, Zaid H. Tafesh, Arun Jesudian, Vikas Gupta, Robert E. Schwartz, Nick Russo, Christopher J. Danford, Daryl T.Y. Lau, Robert S. Brown, Nidhi Jalan‐Sakrikar, Jessica L. Maiers, Rajani Sharma, Brett E. Fortune, Moira Hilscher, Sayed Obaidullah Aseem – 29 October 2019

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