Tissue Inhibitor of Metalloproteinase 3 Deficiency Disrupts the Hepatocyte E‐Cadherin/β‐Catenin Complex and Induces Cell Death in Liver Ischemia/Reperfusion Injury
Takehiro Fujii, Sergio Duarte, Eudora Lee, Bibo Ke, Ronald W. Busuttil, Ana J. Coito – 22 October 2019 – Tissue inhibitor of metalloproteinase (TIMP) 3 is a naturally occurring inhibitor of a broad range of proteases, with key roles in extracellular matrix turnover and in the pathogenesis of various diseases. In this study, we investigated the response of mice lacking TIMP3 (TIMP3−/−) to hepatic ischemia/reperfusion injury (IRI).