Issue Information
1 March 2020
Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial
Keyur Patel, Stephen A. Harrison, Magdy Elkhashab, James F. Trotter, Robert Herring, Sergio E. Rojter, Zeid Kayali, Vincent Wai‐Sun Wong, Susan Greenbloom, Saumya Jayakumar, Mitchell L. Shiffman, Bradley Freilich, Eric J. Lawitz, Edward J. Gane, Eliza Harting, Jun Xu, Andrew N. Billin, Chuhan Chung, C. Stephen Djedjos, G. Mani Subramanian, Robert P. Myers, Michael S. Middleton, Mary Rinella, Mazen Noureddin – 1 March 2020
Activation of Estrogen Receptor G Protein–Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice
Helen H. Wang, Ornella Bari, Christopher K. Arnatt, Min Liu, Piero Portincasa, David Q.‐H. Wang – 29 February 2020
Impact of Immune Response on Outcomes in Hepatocellular Carcinoma: Association With Vascular Formation
Shinji Itoh, Tomoharu Yoshizumi, Kyohei Yugawa, Daisuke Imai, Shohei Yoshiya, Kazuki Takeishi, Takeo Toshima, Noboru Harada, Toru Ikegami, Yuji Soejima, Kenichi Kohashi, Yoshinao Oda, Masaki Mori – 29 February 2020
Longterm Survival After Liver Transplantation for Autoimmune Hepatitis: Results From the European Liver Transplant Registry
Melina Heinemann, Rene Adam, Marina Berenguer, Darius Mirza, Seyed Ali Malek‐Hosseini, John G.
Decreased Hepatocyte Autophagy Leads to Synergistic IL‐1β and TNF Mouse Liver Injury and Inflammation
Yang Shen, Shoaib Ahmad Malik, Muhammad Amir, Pradeep Kumar, Francesca Cingolani, Jing Wen, Yunshan Liu, Enpeng Zhao, Alton B. Farris, Reben Raeman, Mark J. Czaja – 28 February 2020
Decreased Hepatocyte Autophagy Leads to Synergistic IL‐1β and TNF Mouse Liver Injury and Inflammation
Yang Shen, Shoaib Ahmad Malik, Muhammad Amir, Pradeep Kumar, Francesca Cingolani, Jing Wen, Yunshan Liu, Enpeng Zhao, Alton B. Farris, Reben Raeman, Mark J. Czaja – 28 February 2020
Hepatitis C Virus Infection in Populations With Liver‐Related Diseases in the Middle East and North Africa
Sarwat Mahmud, Hiam Chemaitelly, Zaina Al Kanaani, Silva P. Kouyoumjian, Laith J. Abu‐Raddad – 28 February 2020 – We investigated hepatitis C virus (HCV) epidemiology in populations with liver‐related diseases (LRDs) in the Middle East and North Africa. The data source was standardized databases of HCV measures populated through systematic reviews. Random‐effects meta‐analyses and meta‐regressions were performed, and genotype diversity was assessed. Analyses were based on 252 HCV antibody prevalence measures, eight viremic rate measures, and 30 genotype measures on 132,358 subjects.
Predicting Survival After Hepatocellular Carcinoma Resection Using Deep Learning on Histological Slides
Charlie Saillard, Benoit Schmauch, Oumeima Laifa, Matahi Moarii, Sylvain Toldo, Mikhail Zaslavskiy, Elodie Pronier, Alexis Laurent, Giuliana Amaddeo, Hélène Regnault, Daniele Sommacale, Marianne Ziol, Jean‐Michel Pawlotsky, Sébastien Mulé, Alain Luciani, Gilles Wainrib, Thomas Clozel, Pierre Courtiol, Julien Calderaro – 28 February 2020
Bile Biochemistry Following Liver Reperfusion in the Recipient and Its Association With Cholangiopathy
Rohit Gaurav, Niroshan Atulugama, Lisa Swift, Andrew J. Butler, Sara Upponi, Rebecca Brais, Michael Allison, Christopher J. E. Watson – 28 February 2020 – Cholangiocytes secrete bicarbonate and absorb glucose, producing bile with alkaline pH and low glucose content. These functions of cholangiocytes have been suggested as a marker of bile duct viability during normothermic ex situ liver perfusion, and they are now monitored routinely after reperfusion in our center.