Coronavirus Disease 2019 in Autoimmune Hepatitis: A Lesson From Immunosuppressed Patients

Alessio Gerussi, Cristina Rigamonti, Chiara Elia, Nora Cazzagon, Annarosa Floreani, Roberta Pozzi, Pietro Pozzoni, Ernesto Claar, Luisa Pasulo, Stefano Fagiuoli, Laura Cristoferi, Marco Carbone, Pietro Invernizzi – 9 June 2020 – Chronic immunosuppression is associated with increased and more severe viral infections. However, little is known about the association between immunosuppression and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection.

Prophylactic Strategy Against De Novo Hepatitis B Virus Infection for Pediatric Recipients Who Receive Hepatitis B Core Antibody–Positive Liver Grafts

Zhuolun Song, Chong Dong, Xingchu Meng, Chao Sun, Kai Wang, Hong Qin, Chao Han, Yang Yang, Fubo Zhang, Weiping Zheng, Jing Chen, Keran Duan, Bowen Bi, Wei Gao – 8 June 2020 – The goal of this study was to evaluate the efficacy of a perioperative prophylactic strategy against de novo hepatitis B virus (HBV) infection in pediatric liver transplantation (LT) recipients with hepatitis B core antibody (HBcAb)–positive grafts. A total of 482 pediatric recipients transplanted between 2013 and 2017 were enrolled, and 170 recipients received HBcAb‐positive liver grafts.

Glutathione S‐Transferase T1 Mismatch Is a Risk Factor for Chronic Ductopenic Rejection of Liver Allografts

Jose Manuel Sousa, Lydia Barrera, Miguel Angel Gomez‐Bravo, Antonio Nuñez‐Roldan, Isabel Aguilera – 8 June 2020 – The underlying causes of chronic rejection (CR) after liver transplantation (LT) are not completely known. The main aim of this study was to explore the involvement of the minor histocompatibility antigen glutathione S‐transferase T1 (GSTT1) in CR. We retrospectively studied 611 patients who underwent LTs at University Hospital Virgen del Rocío between 2003 and 2016 with a median follow‐up of 7.4 ± 4.2 years. The GSTT1 genotype was determined by polymerase chain reaction.

Etiology of Liver Steatosis Influences the Severity of Ischemia/Reperfusion Injury and Survival After Liver Transplantation in Rats

Yosuke Miyachi, Shintaro Yagi, Masaaki Hirata, Sena Iwamura, Siyuan Yao, Hisaya Shirai, Shinya Okumura, Taku Iida, Takashi Ito, Ryuji Uozumi, Toshimi Kaido, Shinji Uemoto – 8 June 2020 – Liver steatosis is a leading cause of graft disposal in liver transplantation, though the degree of steatosis is often the single factor determining acceptability of the graft. We investigated how the cause of liver steatosis affects graft function in rat orthotopic liver transplantation (OLT).

Genomics and Liver Transplantation: Genomic Biomarkers for the Diagnosis of Acute Cellular Rejection

Taisa J. Kohut, Jose F. Barandiaran, Brendan J. Keating – 7 June 2020 – Acute cellular rejection (ACR) is a common complication in liver transplantation recipients (LTRs), especially within the first 12 months, and it is associated with increased morbidity and mortality. Although abnormalities in standard liver biochemistries may raise the clinical suspicion for ACR, it lacks specificity, and invasive liver biopsies, which are associated with numerous risks, are required for definitive diagnoses.

Subscribe to