Unequal Effects of Myosin 5B Mutations in Liver and Intestine Determine the Clinical Presentation of Low‐Gamma‐Glutamyltransferase Cholestasis
Sven C.D. IJzendoorn, Qinghong Li, Yi‐ling Qiu, Jian‐She Wang, Arend W. Overeem – 24 June 2020
Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps
Ariel Jaffe, Michael L. Schilsky, Ranjit Deshpande, Ramesh Batra – 23 June 2020 – The recent outbreak of the novel virus severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), which causes the corona virus disease of 2019 (COVID19), has spread globally and affects millions of people. This pandemic has taxed our health care system and disrupted normal operations, even life‐saving procedures, such as liver transplants. During these unprecedented times, providers and patients are imperiled and resources for diagnosis and care may be limited.
Pushing the Limits in Donation After Circulatory Death Donor Selection: Optimizing Graft Rehabilitation With Ex Vivo Machine Perfusion
Paolo Magistri, Tiziana Olivieri, Cristiano Guidetti, Gian Piero Guerrini, Vanni Agnoletti, Paolo Muiesan, Fabrizio Di Benedetto – 23 June 2020
Longterm Outcomes of Patients Undergoing Liver Transplantation for Acute‐on‐Chronic Liver Failure
Vinay Sundaram, Nadim Mahmud, Giovanni Perricone, Dev Katarey, Robert J. Wong, Constantine J. Karvellas, Brett E. Fortune, Robert S. Rahimi, Harapriya Maddur, Janice H. Jou, Michael Kriss, Lance L. Stein, Moses Lee, Rajiv Jalan, the Multi‐Organ Dysfunction, Evaluation for Liver Transplantation (MODEL) Consortium – 23 June 2020 – Recent data have demonstrated >80% 1‐year survival probability after liver transplantation (LT) for patients with severe acute‐on‐chronic liver failure (ACLF). However, longterm outcomes and complications are still unknown for this population.
Role of Terlipressin and Albumin for Hepatorenal Syndrome in Liver Transplantation
Pratima Sharma, Kevin Moore, Daniel Ganger, Priya Grewal, Robert S. Brown – 23 June 2020 – Hepatorenal syndrome (HRS) is one of the most ominous complications of portal hypertension in patients with decompensated cirrhosis and ascites. It is associated with very high mortality on the wait list. Liver transplantation (LT) is the most successful therapeutic option for patients with HRS.
Opioid Minimization After Liver Transplantation: Results of a Novel Pilot Study
Tiffany C. Lee, Lacey Bittel, Tiffany E. Kaiser, R. Cutler Quillin, Courtney Jones, Shimul A. Shah – 23 June 2020
Liver Transplantation in the Time of COVID19: Barriers and Ethical Considerations for Management and Next Steps
Ariel Jaffe, Michael L. Schilsky, Ranjit Deshpande, Ramesh Batra – 23 June 2020 – The recent outbreak of the novel virus severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2), which causes the corona virus disease of 2019 (COVID19), has spread globally and affects millions of people. This pandemic has taxed our health care system and disrupted normal operations, even life‐saving procedures, such as liver transplants. During these unprecedented times, providers and patients are imperiled and resources for diagnosis and care may be limited.
Nonalcoholic Fatty Liver Disease Increases the Risk of Anxiety and Depression
Christian Labenz, Yvonne Huber, Maurice Michel, Michael Nagel, Peter R. Galle, Karel Kostev, Jörn M. Schattenberg – 22 June 2020 – Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, and data on mutual influence are inconsistent. The aim of this study was to explore the incidence of depression and anxiety in a large primary care cohort in Germany and to study the impact of NAFLD over a 10‐year time frame.
An Endoplasmic Reticulum Stress–MicroRNA‐26a Feedback Circuit in NAFLD
Haixia Xu, Yan Tian, Dongmei Tang, Sailan Zou, Geng Liu, Jiulin Song, Guixiang Zhang, Xiao Du, Wei Huang, Bin He, Weiqiang Lin, Liang Jin, Wendong Huang, Jiayin Yang, Xianghui Fu – 22 June 2020
The Microbiome and Hepatocellular Carcinoma
Puru Rattan, Carlos D. Minacapelli, Vinod Rustgi – 21 June 2020 – The human microbiome is a vast and complex system encompassing all of the microbes and their genes that occupy the environmentally exposed surfaces of the human body. The gut microbiota and its associated microbiome play an integral role in mammalian metabolism and immune tolerance as well as in immunocompetence. Disruptions in the human gut microbiome are associated with a cycle of hepatocyte injury and regeneration characteristic of chronic liver disease.