Small Steatotic HCC: A Radiological Variant Associated With Improved Outcome After Ablation

Margaux Hermida, Ancelin Preel, Eric Assenat, Lauranne Piron, Christophe Cassinotto, José Ursic‐Bedoya, Chloé Guillot, Astrid Herrero, Fabrizio Panaro, Georges‐Philippe Pageaux, Boris Guiu – 31 December 2020 – Percutaneous thermal ablation is a validated treatment option for small hepatocellular carcinoma (HCC). Steatotic HCC can be reliably detected by magnetic resonance imaging.

Rotor Syndrome: Glucuronidated Bile Acidemia From Defective Reuptake by Hepatocytes

Akihiko Kimura, Tatehiro Kagawa, Hajime Takei, Yoshihiro Maruo, Hiroshi Sakugawa, Takahiro Sasaki, Tsuyoshi Murai, Nakayuki Naritaka, Hajime Takikawa, Hiroshi Nittono – 31 December 2020 – Organic anion transporting polypeptide (OATP) 1B1 (gene, solute carrier organic anion transporter family member 1B1 [SLCO1B1]) and OATP1B3 (SLCO1B3) serve as transporters for hepatic uptake of important endogenous substances and several commonly prescribed drugs. Inactivation of both proteins together causes Rotor syndrome. How this OATP1B1/1B3 defect disturbs bile acid (BA) metabolism is largely unknown.

ARID1A Deficiency Is Associated With High Programmed Death Ligand 1 Expression in Hepatocellular Carcinoma

Norifumi Iseda, Shinji Itoh, Tomoharu Yoshizumi, Kyohei Yugawa, Akinari Morinaga, Takahiro Tomiyama, Takeo Toshima, Kenichi Kohashi, Yoshinao Oda, Masaki Mori – 30 December 2020 – The clinicopathological features of carcinomas expressing AT‐rich interaction domain 1a (ARID1A) and programmed death ligand 1 (PD‐L1) in HCC are poorly understood. Here, we examined ARID1A and PD‐L1 expression in surgically resected primary hepatocellular carcinoma (HCC) and the association of ARID1A and PD‐L1 expression with clinicopathological features and patient outcomes.

Lipoprotein Insulin Resistance Index Reflects Liver Fat Content in Patients With Nonalcoholic Fatty Liver Disease

Anusha Vittal, Mark Shapses, Bashar Sharma, Disha Sharma, Qian Sun, Maureen Sampson, Wilson Lee, Gil Ben Yakov, Yaron Rotman – 29 December 2020 – The recently developed lipoprotein insulin resistance index (LP‐IR) incorporates lipoprotein particle numbers and sizes and is considered to reflect both hepatic and peripheral IR. As tissue IR is a strong component of nonalcoholic fatty liver disease (NAFLD) pathogenesis, we aimed to assess the degree by which LP‐IR associates with hepatic fat content. This was a single‐center retrospective analysis of patients with NAFLD.

Efficiently Restored Thrombopoietin Production by Ashwell‐Morell Receptor and IL‐6R Induced Janus Kinase 2/Signal Transducer and Activator of Transcription Signaling Early After Partial Hepatectomy

Friedrich Reusswig, Nastaran Fazel Modares, Marius Brechtenkamp, Leonard Wienands, Irena Krüger, Kristina Behnke, Melissa M. Lee‐Sundlov, Diran Herebian, Jürgen Scheller, Karin M. Hoffmeister, Dieter Häussinger, Margitta Elvers – 28 December 2020

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