Neurodegeneration in Hepatic and Neurologic Wilson’s Disease

André Viveiros, Vincent Beliveau, Marlene Panzer, Benedikt Schaefer, Bernhard Glodny, Benjamin Henninger, Herbert Tilg, Heinz Zoller, Christoph Scherfler – 14 December 2020 – Clinical presentation of Wilson disease (WD) includes hepatic and neurologic manifestations. This study compares subcortical brain regions by magnetic resonance imaging in patients with WD and without neurological symptoms. Distinct atrophy affecting the basal ganglia, accumbens, and hippocampus was present in neurological WD. Cerebellar atrophy was observed in hepatic WD without neurological symptoms.

Two Faces of Neutrophils in Liver Disease Development and Progression

Yeonhee Cho, Gyongyi Szabo – 13 December 2020 – Neutrophils, the most abundant type of leukocyte in human blood, play a major role in host defense against invading pathogens and in sterile injury. Neutrophil infiltration is characteristic of inflammation because of its antimicrobial and cytotoxic activities. Neutrophils also actively participate in the resolution of inflammation and subsequent tissue repair by acting as a critical mediator between the inflammation and resolution phases of tissue damage.

Reduced Clot Stability by Thromboelastography as a Potential Indicator of Procedure‐Related Bleeding in Decompensated Cirrhosis

Alberto Zanetto, Henry M. Rinder, Marco Senzolo, Paolo Simioni, Guadalupe Garcia‐Tsao – 12 December 2020 – In patients with decompensated cirrhosis, procedure‐related bleeding is a potentially lethal complication. Routine coagulation tests such as international normalized ratio and platelet count do not predict bleeding risk. We investigated whether thromboelastography (TEG) can identify patients with cirrhosis who are at risk of procedure‐related bleeding.

Posttransplant Outcomes in Older Patients With Hepatocellular Carcinoma Are Driven by Non–Hepatocellular Carcinoma Factors

Nia Adeniji, Vinodhini Arjunan, Vijay Prabhakar, Ajitha Mannalithara, Tara Ghaziani, Aijaz Ahmed, Paul Kwo, Mindie Nguyen, Marc L. Melcher, Ronald W. Busuttil, Sander S. Florman, Brandy Haydel, Richard M. Ruiz, Goran B. Klintmalm, David D. Lee, C. Burcin Taner, Maarouf A. Hoteit, Elizabeth C. Verna, Karim J. Halazun, Amit D. Tevar, Abhinav Humar, William C. Chapman, Neeta Vachharajani, Federico Aucejo, Trevor L. Nydam, James F. Markmann, Constance Mobley, Mark Ghobrial, Alan N. Langnas, Carol A. Carney, Jennifer Berumen, Gabriel T. Schnickel, Debra L. Sudan, Johnny C.

Adenosine Diphosphate and the P2Y13 Receptor Are Involved in the Autophagic Protection of Ex Vivo Perfused Livers From Fasted Rats: Potential Benefit for Liver Graft Preservation

Bérengère Papegay, Vincent Nuyens, Adelin Albert, Mustapha Cherkaoui‐Malki, Pierre Andreoletti, Oberdan Leo, Véronique Kruys, Jean G. Boogaerts, Joseph Vamecq – 11 December 2020 – Studies on how to protect livers perfused ex vivo can help design strategies for hepatoprotection and liver graft preservation. The protection of livers isolated from 24‐hour versus 18‐hour starved rats has been previously attributed to autophagy, which contributes to the energy‐mobilizing capacity ex vivo. Here, we explored the signaling pathways responsible for this protection.

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