The Use of Rifaximin in Patients With Cirrhosis

Paolo Caraceni, Victor Vargas, Elsa Solà, Carlo Alessandria, Koos Wit, Jonel Trebicka, Paolo Angeli, Rajeshwar P. Mookerjee, François Durand, Elisa Pose, Aleksander Krag, Jasmohan S. Bajaj, Ulrich Beuers, Pere Ginès, for the Liverhope Consortium – 8 January 2021 – Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and broad‐spectrum antibacterial activity covering both gram‐positive and gram‐negative organisms.

Clinical Presentation and Gene Expression of Acute Alcohol‐Induced Microvesicular Steatosis Mimicking Alcoholic Hepatitis

Laurent Spahr, Nicolas Lanthier, Mathieu Tihy, Jean‐Louis Frossard, Laura Rubbia‐Brandt, Nicolas Goossens – 8 January 2021 – Acute alcoholic microvesicular steatosis (MIC) may complicate heavy alcohol intake and present as alcoholic hepatitis (AH) syndrome. However, detailed clinical, biological, and histologic data associated with MIC are scarce. We compared the clinical presentation, histologic features, and hepatic transcriptomic of patients presenting with AH due to either MIC or severe alcoholic steatohepatitis (ASH).

Advanced Techniques and Awaited Clinical Applications for Human Pluripotent Stem Cell Differentiation into Hepatocytes

Eléanor Luce, Antonietta Messina, Jean‐Charles Duclos‐Vallée, Anne Dubart‐Kupperschmitt – 7 January 2021 – Liver transplantation is currently the only curative treatment for several liver diseases such as acute liver failure, end‐stage liver disorders, primary liver cancers, and certain genetic conditions. Unfortunately, despite improvements to transplantation techniques, including live donor transplantation, the number of organs available remains insufficient to meet patient needs.

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