J. Mark Farrant, Derek G. Doherty, Peter T. Donaldson, Robert W. Vaughan, Karen M. Hayllar, Ken I. Welsh, Adrian L. W. F. Eddleston, Roger Williams – 1 August 1992 – Previous studies based on serological HLA phenotyping have implicated genes in the HLA class II region in susceptibility to and protection from primary sclerosing cholangitis. In a recent report, the HLA DRw52a antigen was present in all 29 patients who had been referred for liver transplantation.

Kenneth Devaney, Zachary D. Goodman, Kamal G. Ishak – 1 August 1992 – Giant‐cell hepatitis is a frequent pattern of liver injury in the neonate, but it is rare after infancy. Such cases have been attributed to autoimmune disease, to non‐A, non‐B hepatitis and, most recently, to paramyxovirus infection. To better define the entity of postinfantile (syncytial) giant‐cell hepatitis, we reviewed 24 biopsy specimens from 20 patients with this finding, either alone or in combination with other diagnoses. The number of multinucleated giant cells varied greatly from one specimen to another.

Yasushi Shiratori, Ryo Nakata, Ken'ichi Okano, Yutaka Komatsu, Shuichiro Shiina, Tateo Kawase, Tsuneaki Sugimoto, Masao Omata, Mitsugu Tanaka – 1 August 1992 – This study investigates the role of hepatic asialo GM1–positive cells in inhibiting hepatic metastasis of colon carcinoma (colon adenocarcinoma 38) in mice after administration of a biological response modifier, streptococcal derivative (OK432).

Mauro Bernardi, Claudio de Marco, Franco Trevisani, Carlo de Collibus, Lorenzo Fornalé, Mario Baraldini, Pietro Andreone, Carmela Cursaro, Fabio Zacá, Amedeo Ligabue, Giovanni Gasbarrini – 1 August 1992 – To assess the hemodynamic status of patients with compensated cirrhosis, mean arterial pressure, cardiac index and peripheral vascular resistance and markers of central (plasma concentrations of atrial natriuretic factor) and arterial volemia (plasma norepinephrine concentration, plasma renin activity) were studied in 10 patients and 10 healthy control subjects under steady‐state condition

1 August 1992

Moritaka Goto, Yoshiyuki Takei, Sunao Kawano, Shingo Tsuji, Hiroyuki Fukui, Hiroaki Fushimi, Yoshiya Nishimura, Toru Kashiwagi, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1992 – This study examines whether tumor necrosis factor and endotoxin are involved in the pathogenesis of primary nonfunction of graft and pulmonary complication after orthotopic liver transplantation. Livers from Lewis rats were stored for either 1 or 4 hr in ice‐cold Euro‐Collins solution (1‐hr storage and 4‐hr storage group, respectively). Subsequently, donor livers were implanted orthotopically.

Yuji Tanaka, Norio Hayashi, Akira Kaneko, Toshifumi Ito, Eiji Miyoshi, Yutaka Sasaki, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1992 – Digital imaging fluorescence microscopy has been used to investigate epidermal growth factor–induced calcium responses of fura‐2–loaded hepatocytes in primary culture at the single‐cell level. Epidermal growth factor induced oscillations in cytosolic free calcium ([Ca2+]i) consisting of a periodic train of spikes unlike the monophasic elevation in cell suspensions reported previously.

Toshihiro Mitaka, Michihide Mikami, Gerald L. Sattler, Henry C. Pitot, Yohichi Mochizuki – 1 August 1992 – Colonies of small hepatocytes appeared after the culture of primary adult rat hepatocytes for 4 days in serum‐free modified Dulbecco's modified Eagle's medium containing 10 mmol/L nicotinamide and 10 ng/ml epidermal growth factor. Each colony consisted of cells that had a single nucleus and a higher nucleus/cytoplasm ratio than surrounding hepatocytes, and immunocytochemically these cells were stained with albumin and transferrin.

Takechika Fujii, Michimori Kohno, Chisato Hirayama – 1 August 1992 – Urinary 15N‐ammonia and 15N‐urea were measured by gas chromatography‐mass spectrometry after the intravenous administration of 15N‐ammonia (0.2 μmol/kg/hr) to 6 volunteers and 11 patients with cirrhosis. Urinary 15N‐nitrogen excretion as ammonia and urea was measured during the 210‐min infusion period, and urea synthesis and ammonia conversion to amino acids were analyzed with a three‐compartment model using the nonlinear least‐squares method.

Beat Hornstein, Lukas Stammler, Leonardo Bianchi, Lukas Landmann – 1 July 1992 – Structural alterations of liver parenchyma caused by ethinylestradiol, a synthetic estrogen known to induce cholestasis and to act as a tumor promoter factor, were investigated. Male rats treated with 17α‐ethinylestradiol (5 mg/kg body weight for 5 days) were compared with controls (n = 5 each). After perfusion fixation and systematic random sampling, paraffin sections, semithin sections and thin sections were examined observing standard stereological techniques.