Ian Homer Y. Cua, Jason M. Hui, Priyanka Bandara, James G. Kench, Geoffrey C. Farrell, Geoffrey W. McCaughan, Jacob George – 27 June 2007 – The role of tumor necrosis factor α, interleukin 6, leptin, and adiponectin in the pathogenesis of hepatitis C virus (HCV)‐associated insulin resistance (IR) remains controversial.
Wei‐Hong Wen, Jia‐Yun Liu, Wei‐Jun Qin, Jing Zhao, Tao Wang, Lin‐Tao Jia, Yan‐Ling Meng, Hui Gao, Cai‐Fang Xue, Bo‐Quan Jin, Li‐Bo Yao, Si‐Yi Chen, An‐Gang Yang – 27 June 2007 – RNA interference is highly effective at inhibiting HBV gene expression and replication. However, before small interfering RNA (siRNA) can be used in the clinic, it is essential to develop a system to target their delivery. Antibody‐mediated delivery is a novel approach for targeting siRNA to appropriate cells. In this report, we asked whether this siRNA delivery strategy would be effective against HBV.
Valerie S. Calvert, Rochelle Collantes, Hazem Elariny, Arian Afendy, Ancha Baranova, Michael Mendoza, Zachary Goodman, Lance A. Liotta, Emanuel F. Petricoin, Zobair M. Younossi – 27 June 2007 – Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. Omental adipose tissue, a biologically active organ secreting adipokines and cytokines, may play a role in the development of NAFLD. We tested this hypothesis with reverse‐phase protein microarrays (RPA) for multiplexed cell signaling analysis of adipose tissue from patients with NAFLD.
Jonel Trebicka, Martin Hennenberg, Wim Laleman, Nataliya Shelest, Erwin Biecker, Michael Schepke, Frederik Nevens, Tilman Sauerbruch, Jörg Heller – 27 June 2007 – In cirrhosis, increased RhoA/Rho‐kinase signaling and decreased nitric oxide (NO) availability contribute to increased intrahepatic resistance and portal hypertension. Hepatic stellate cells (HSCs) regulate intrahepatic resistance. 3‐Hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitors (statins) inhibit synthesis of isoprenoids, which are necessary for membrane translocation and activation of small GTPases like RhoA and Ras.
Masahiko Koda, Yoshikazu Murawaki – 27 June 2007
Wenchen Kenneth Wu, Mei Sheng Duh, Patrick Lefebvre – 27 June 2007
Abigail Fraser, Shah Ebrahim, George Davey Smith, Debbie A. Lawlor – 27 June 2007 – Associations between biomarkers of nonalcoholic fatty liver disease (NAFLD) alanine aminotransferase (ALT), and gamma‐glutamyltransferase (GGT), with 3 separate measures of glucose homeostasis: fasting glucose, fasting insulin and glycated hemoglobin (HbA1c) were studied and compared between women with and without diabetes in order to gain insight into the documented associations between NAFLD, insulin resistance and diabetes.
Brent A. Neuschwander‐Tetri – 27 June 2007
Anna S. Lok, Fabien Zoulim, Stephen Locarnini, Angeline Bartholomeusz, Marc G. Ghany, Jean‐Michel Pawlotsky, Yun‐Fan Liaw, Masashi Mizokami, Carla Kuiken – 27 June 2007 – Substantial advances have been made in the treatment of chronic hepatitis B in the past decade. Approved treatments for chronic hepatitis B include 2 formulations of interferon and 4 nucleos(t)ide analogues (NAs).
Valérie Paradis, Axelle Champault, Maxime Ronot, Lydia Deschamps, Dominique‐Charles Valla, Dominique Vidaud, Valérie Vilgrain, Jacques Belghiti, Pierre Bedossa – 27 June 2007 – What were previously called telangiectatic focal nodular hyperplasias are in fact true adenomas with telangiectatic features (TAs) without overt characterized genetic abnormalities. The aim of our study was to review a surgical series of TAs in order to describe clinical, biological, and radiological findings of these lesions and to evaluate their outcomes.