Lentivirus‐mediated RNA interference targeting enhancer of zeste homolog 2 inhibits hepatocellular carcinoma growth through down‐regulation of stathmin

Yangchao Chen, Marie C. Lin, Hong Yao, Hua Wang, Ai‐Qun Zhang, Jun Yu, Chee‐kin Hui, George K. Lau, Ming‐liang He, Joseph Sung, Hsiang‐fu Kung – 27 June 2007 – Enhancer of zeste homolog 2 (EZH2) has been shown to be overexpressed in hepatocellular (HCC). We investigated the potential role of EZH2 in HCC tumorigenesis and examined the usefulness of RNA interference (RNAi) targeting EZH2 as a form of HCC treatment. Lentivirus‐mediated RNAi was employed to knock‐down EZH2 expression in human hepatoma cells to study the function of EZH2 in tumorigenesis and evaluate the treatment efficacy.

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Nathalie Ganne‐Carrié, Marianne Ziol, Victor de Ledinghen, Catherine Douvin, Patrick Marcellin, Laurent Castera, Daniel Dhumeaux, Jean‐Claude Trinchet, Michel Beaugrand – 27 June 2007

Serial circulating markers of inflammation in biliary atresia—Evolution of the post‐operative inflammatory process

Bommayya Narayanaswamy, Christopher Gonde, J. Michael Tredger, Munther Hussain, Diego Vergani, Mark Davenport – 27 June 2007 – Biliary atresia (BA) may be characterized as an occlusive cholangiopathy affecting both intra‐ and extra‐hepatic parts of the biliary tree, together with a pronounced inflammatory response consisting of hepatic infiltration of (predominantly) CD4+ lymphocytes and macrophages. Soluble cellular adhesion molecules are also known to be raised at the time of portoenterostomy, presumably reflecting intrahepatic disease.

Adipose tissue‐derived mesenchymal stem cells as a source of human hepatocytes

Agnieszka Banas, Takumi Teratani, Yusuke Yamamoto, Makoto Tokuhara, Fumitaka Takeshita, Gary Quinn, Hitoshi Okochi, Takahiro Ochiya – 27 June 2007 – Recent observations indicate that several stem cells can differentiate into hepatocytes; thus, cell‐based therapy is a potential alternative to liver transplantation. The goal of the present study was to examine the in vitro hepatic differentiation potential of adipose tissue‐derived mesenchymal stem cells (AT‐MSCs).

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