Identification of plasma membrane autoantigens in autoimmune hepatitis type 1 using a proteomics tool

Fatima Tahiri, François Le Naour, Stéphanie Huguet, René Lai‐Kuen, Didier Samuel, Catherine Johanet, Bruno Saubamea, Viviane Tricottet, Jean‐Charles Duclos‐Vallee, Eric Ballot – 27 February 2008 – Autoimmune hepatitis (AIH) is a liver disease with circulating autoantibodies predominantly directed against widely held cellular components. Because AIH is a liver‐specific disease, autoantibodies against plasma membrane antigens may be involved in its pathogenesis and have been reported; however, no definite identification has been described.

Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation

Hideyoshi Toyokawa, Atsunori Nakao, Robert J. Bailey, Michael A. Nalesnik, Takashi Kaizu, Jerome L. Lemoine, Atsushi Ikeda, Koji Tomiyama, Glenn D. Papworth, Leaf Huang, Anthony J. Demetris, Thomas E. Starzl, Noriko Murase – 27 February 2008 – The interaction of donor passenger leukocytes and host leukocytes in recipient secondary lymphoid tissues during the early posttransplantation period is crucial in directing host immune reactions toward allograft rejection or acceptance. Responsible T cell clones could be activated through the direct and indirect pathways of allorecognition.

Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon‐induced antiviral protein in human hepatocyte cells

Kumi Hirano, Tatsuki Ichikawa, Kazuhiko Nakao, Azusa Matsumoto, Hisamitsu Miyaaki, Hidetaka Shibata, Susumu Eguchi, Mitsuhisa Takatsuki, Masanori Ikeda, Hironori Yamasaki, Nobuyuki Kato, Takashi Kanematsu, Nobuko Ishii, Katsumi Eguchi – 27 February 2008 – The premise of our study is that selective inhibition of interferon (IFN) by calcineurin inhibitors contribute to the increased severity of hepatitis C virus (HCV) posttransplantation.

Continuous right ventricular end diastolic volume and right ventricular ejection fraction during liver transplantation: A multicenter study

Giorgio Della Rocca, Maria Gabriella Costa, Paolo Feltracco, Gianni Biancofiore, Bruno Begliomini, Stefania Taddei, Cecilia Coccia, Livia Pompei, Pierangelo Di Marco, Paolo Pietropaoli – 27 February 2008 – Cardiac preload is traditionally considered to be represented by its filling pressures, but more recently, estimations of end diastolic volume of the left or right ventricle have been shown to better reflect preload.

A molecular link between inflammation and fibrogenesis: The bacterial microflora influences hepatic fibrosis via toll‐like receptor 4–dependent modification of transforming growth factor‐β signaling in hepatic stellate cells

Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis

Rubén Francés, Pedro Zapater, José M. González‐Navajas, Carlos Muñoz, Rocío Caño, Rocío Moreu, Sonia Pascual, Pablo Bellot, Miguel Pérez‐Mateo, José Such – 27 February 2008 – Bacterial infections and severity of associated inflammatory reaction influence prognosis in patients with advanced cirrhosis. We compared the innate immune response to bacterial DNA (bactDNA) translocation with that caused by viable bacteria translocation in patients with spontaneous bacterial peritonitis and the relationship between the cytokine response and serum levels of bactDNA.

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