Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver

M. Behnan Sahin, Robert E. Schwartz, Shannon M. Buckley, Yves Heremans, Lucas Chase, Wei‐Shou Hu, Catherine M. Verfaillie – 27 February 2008 – Widespread use of liver transplantation in the treatment of hepatic diseases is restricted by the limited availability of donated organs. One potential solution to this problem would be isolation and propagation of liver progenitor cells or stem cells. Here, we report on the isolation of a novel progenitor cell population from unmanipulated (that is, no prior exposure to chemicals and no injury) adult rat liver.

Safety and efficacy of combined use of sildenafil, bosentan, and iloprost before and after liver transplantation in severe portopulmonary hypertension

Mark J. Austin, Neil I. McDougall, Julia A. Wendon, Elizabeth Sizer, Alex S. Knisely, Mohammed Rela, Carol Wilson, Michael E. Callender, John G. O'Grady, Michael A. Heneghan – 27 February 2008 – Portopulmonary hypertension (PPHTN) represents a constrictive pulmonary vasculopathy in patients with portal hypertension. Liver transplantation (LT) may be curative and is usually restricted to patients with mild‐to‐moderate disease severity characterized by a mean pulmonary artery pressure (mPAP < 35 mm Hg).

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