Reply: Prophylactic variceal ligation is not recommended for patients awaiting live donor liver transplant
Lorenzo Norberto, Andrew Burroughs, Lino Polese – 26 March 2008
Correlation between the liver temperature employed during machine perfusion and reperfusion damage: Role of Ca2+
Mariapia Vairetti, Andrea Ferrigno, Vittoria Rizzo, Eleonora Boncompagni, Amedeo Carraro, Enrico Gringeri, Gloria Milanesi, Sergio Barni, Isabel Freitas, Umberto Cillo – 26 March 2008 – This study compares the effects of machine perfusion (MP) at different temperatures with simple cold storage. In addition, the role of Ca2+ levels in the MP medium was evaluated. For MP, rat livers were perfused for 6 hours with Krebs‐Henseleit (KH) solution (with 1.25 or 2.5 mM CaCl2) at 4°C, 10°C, 20°C, 25°C, 30°C, or 37°C.
The reperfusion syndrome: Have we made any progress?
Michael Ramsay – 26 March 2008
Value of an individual liver biopsy in the preoperative evaluation of apparently healthy potential liver donors
Nurten Savas, Mehmet Coskun, Banu Bilezikci, Irfan Uruc, Hamdi Karakayali, Ugur Yilmaz, Mehmet Haberal – 26 March 2008 – Living donor liver transplantation has acquired widespread acceptance. A thorough workup of the potential living donor is guided by 2 objectives: the first is ensuring the safety of the surgical procedure for the donor, and the second is identifying donor grafts that pose potential risks for the recipient. Of 305 living‐related liver donors, liver biopsy was performed in 201.
Antibody to hepatitis B surface antigen trough levels and half‐lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation
Nazanin Hooman, Kinan Rifai, Johannes Hadem, Bernhard Vaske, Gunnar Philipp, Andrea Priess, Juergen Klempnauer, Hans L. Tillmann, Michael P. Manns, Jens Rosenau – 26 March 2008 – Hepatitis B immunoglobulin (HBIG) administration remains an essential component of standard reinfection prophylaxis after liver transplantation for hepatitis B virus–related liver disease. Previous studies have suggested that intramuscular (IM) HBIG administration compared to intravenous (IV) HBIG administration may be cost‐effective and dose‐saving.
First, do no harm: The question of liver biopsy in living liver donors
Kim M. Olthoff, K. Rajender Reddy – 26 March 2008
Strategies to protect the transplanted liver from hepatitis B virus infection
Timothy L. Pruett – 26 March 2008
The impact of postreperfusion syndrome on short‐term patient and liver allograft outcome in patients undergoing orthotopic liver transplantation
Ibtesam Hilmi, Charles N. Horton, Raymond M. Planinsic, Tetsuro Sakai, Ramona Nicolau‐Raducu, Daniela Damian, Silivu Gligor, Amadeo Marcos – 26 March 2008 – The greatest part of liver allograft injury occurs during reperfusion, not during the cold ischemia phase. The aim of this study, therefore, was to investigate how the severity of postreperfusion syndrome (PRS) influences short‐term outcome for the patient and for the liver allograft. Over a 2‐year period, 338 consecutive patients who presented for orthotopic liver transplantation (OLT) were included in this retrospective study.
Treatment of Small‐For‐Size Syndrome
James D. Perkins – 26 March 2008 – The portal hyperperfusion, or small‐for‐size syndrome (SFSS), is a widely recognized clinical complication that may occur after segmental liver transplantation. Several surgical strategies have been proposed to reduce portal blood inflow and portal pressure after partial liver transplantation. In particular, splenic artery ligation and splenectomy have been used without a firm hemodynamic basis for these procedures.
Health‐related quality of life and family function following pediatric liver transplantation
Estella M. Alonso, Katie Neighbors, Franca B. Barton, Sue V. McDiarmid, Stephen P. Dunn, George V. Mazariegos, Jeanne M. Landgraf, John C. Bucuvalas – 26 March 2008 – This multicenter study compared health‐related quality of life (HRQOL) and family function of pediatric liver transplant recipients to those of healthy children to determine if this population differed from a healthy population and to distinguish which pretransplant and posttransplant factors impact HRQOL and family function.