Issue Information
15 June 2022
Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B
Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi, Juanjuan Chen, Yuning Wei, Yanfang Pan, Huaixin Dang, Xiong Wei, Ashraf Siddig Yousif, Jeysen Yogaratnam, Qiong Zhou, Henri Lichenstein, Tian Xu – 13 June 2022
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Hiroki Murai, Takahiro Kodama, Tetsuo Takehara – 13 June 2022
Iron overload disorders
Christine C. Hsu, Nizar H. Senussi, Kleber Y. Fertrin, Kris V. Kowdley – 13 June 2022 – Iron overload disorders represent a variety of conditions that lead to increased total body iron stores and resultant end‐organ damage. An elevated ferritin and transferrin‐iron saturation can be commonly encountered in the evaluation of elevated liver enzymes. Confirmatory homeostatic iron regulator (HFE) genetic testing for C282Y and H63D, mutations most encountered in hereditary hemochromatosis, should be pursued in evaluation of hyperferritinemia.
Methyltransferase 1 is required for nonhomologous end‐joining repair and renders hepatocellular carcinoma resistant to radiotherapy
Junbin Liao, Yang Yi, Xin Yue, Xiaoxue Wu, Meiyan Zhu, Yong Chen, Sui Peng, Ming Kuang, Shuibin Lin, Zhenwei Peng – 13 June 2022
Waitlist mortality of young patients with biliary atresia: Impact of allocation policy and living donor liver transplantation
Hedayatullah Esmati, Marieke Rosmalen, Patrick F. Rheenen, Marieke T. Boer, Aad P. Berg, Hubert P. J. Doef, Michel Rayar, Ruben H.J. Kleine, Robert J. Porte, Vincent E. Meijer, Henkjan J. Verkade – 13 June 2022 – Patients with biliary atresia (BA) below 2 years of age in need of a transplantation largely rely on partial grafts from deceased donors (deceased donor liver transplantation [DDLT]) or living donors (living donor liver transplantation [LDLT]).
Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation
Xiaowen Ma, Allen Chen, Luma Melo, Ana Clemente‐Sanchez, Xiaojuan Chao, Ali Reza Ahmadi, Brandon Peiffer, Zhaoli Sun, Hiromi Sesaki, Tiangang Li, Xiaokun Wang, Wanqing Liu, Ramon Bataller, Hong‐Min Ni, Wen‐Xing Ding – 12 June 2022
Letter to the editor: Is it time to change the standard TIPS procedure?
Xuefeng Luo, Li Yang – 12 June 2022