Acute portal hypertension using portal vein ligation abrogates TRAIL expression of liver‐resident NK cells

Yuki Imaoka, Koki Sato, Masahiro Ohira, Kouki Imaoka, Takuya Yano, Ryosuke Nakano, Yuka Tanaka, Hideki Ohdan – 19 June 2022 – The effects of acute portal hypertension (PHT), which is reported as poor prognostic factors in patients with hepatocellular carcinoma, are not well known on the liver immune system, including natural killer (NK) cells. The aim of this study, therefore, was to investigate how acute PHT influences the functions and characteristics of liver‐resident NK (lr‐NK) cells using an acute PHT mouse model.

Spatial transcriptomics identifies enriched gene expression and cell types in human liver fibrosis

Brian K. Chung, Jonas Øgaard, Henrik Mikael Reims, Tom H. Karlsen, Espen Melum – 19 June 2022 – Liver fibrosis and cirrhosis have limited therapeutic options and represent a serious unmet patient need. Recent use of single‐cell RNA sequencing (scRNAseq) has identified enriched cell types infiltrating cirrhotic livers but without defining the microanatomical location of these lineages thoroughly.

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