Camille Sureau, Jessica Salisse – 13 November 2012 – Two determinants of infectivity have been identified in the hepatitis B virus (HBV) envelope proteins: a pre‐S1 receptor‐binding site and an uncharacterized determinant in the antigenic loop (AGL), which is structurally related to the antigenic a‐determinant. Infection would proceed through virus attachment to cell surface heparan sulfate (HS) proteoglycans (HSPGs) before pre‐S1 engages a specific receptor for uptake.

Xijun Wang, Aihua Zhang, Hui Sun – 13 November 2012 – Hepatocellular carcinoma (HCC) is the commonest primary hepatic malignancy and the third most common cause of cancer‐related death worldwide. Incidence remains highest in the developing world and is steadily increasing across the developed world. Current diagnostic modalities, of ultrasound and α‐fetoprotein, are expensive and lack sensitivity in tumor detection. Because of its asymptomatic nature, HCC is usually diagnosed at late and advanced stages, for which there are no effective therapies.

Dhiraj Tripathi – 9 November 2012 – Watch the interview with the author

Harjit K. Bhogal, Arun J. Sanyal – 9 November 2012 – Watch a video presentation of this article

Harjit K. Bhogal, Arun J. Sanyal – 9 November 2012 – Watch a video presentation of this article

Shiv Kumar Sarin, Chandan K. N. Kumar – 9 November 2012 – Watch a video presentation of this article

Douglas A. Simonetto, Vijay H. Shah – 9 November 2012 – Watch the interview with the author

Carlo Merkel, Sara Montagnese – 9 November 2012 – Watch the interview with the author

Christopher Koh, Theo Heller – 9 November 2012 – Watch a video presentation of this article

Simon C. Ling – 9 November 2012 – Watch the interview with the author