Sébastien Anthérieu, Pamela Bachour‐El Azzi, Julie Dumont, Ziad Abdel‐Razzak, Christiane Guguen‐Guillouzo, Bernard Fromenty, Marie‐Anne Robin, André Guillouzo – 23 November 2012 – Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans. Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells.

Luigi Bolondi, Fabio Piscaglia – 23 November 2012

Yun‐Fan Sun, Yang Xu, Xin‐Rong Yang, Wei Guo, Xin Zhang, Shuang‐Jian Qiu, Ruo‐Yu Shi, Bo Hu, Jian Zhou, Jia Fan – 23 November 2012 – Epithelial cell adhesion molecule–positive (EpCAM+) hepatocellular carcinoma (HCC) cells may constitute a tumor‐initiating subpopulation in tumorigenic cell lines and HCC specimens. In the present study, EpCAM+ circulating tumor cells (CTCs) were identified prospectively in HCC patients undergoing curative resection, and the prognostic significance and their stem cell–like characteristics were investigated further.

Lisheng Zhang, Lixin Yang, Xiyong Liu, Wei Chen, Lufen Chang, Linling Chen, Sofia Loera, Peiguo Chu, Wei‐Chien Huang, Yun‐Ru Liu, Yun Yen – 23 November 2012 – Growing evidence indicates that deregulation of microRNAs (miRNAs) contributes to tumorigenesis. Dysregulation of miR‐657 has been observed in several types of cancers, but its biological function is still largely unknown. Our results showed that miR‐657 expression can be induced by hepatitis viral proteins and is significantly increased in hepatocellular carcinoma (HCC) tissues.

Luigi Bolondi, Fabio Piscaglia – 23 November 2012

Shi‐Ying Cai, Daniël A. Lionarons, Lee Hagey, Carol J. Soroka, Albert Mennone, James L. Boyer – 23 November 2012 – The sea lamprey (Petromyzon marinus) is a genetically programmed animal model for biliary atresia, as it loses its bile ducts and gallbladder during metamorphosis. However, in contrast to patients with biliary atresia or other forms of cholestasis who develop progressive disease, the postmetamorphosis lampreys grow normally to adult size.

Nisanne S. Ghonem, James L. Boyer – 23 November 2012

Naoki Kumashiro, Toru Yoshimura, Jennifer L. Cantley, Sachin K. Majumdar, Fitsum Guebre‐Egziabher, Romy Kursawe, Daniel F. Vatner, Ioana Fat, Mario Kahn, Derek M. Erion, Xian‐Man Zhang, Dongyan Zhang, Vara Prasad Manchem, Sanjay Bhanot, Glenn S. Gerhard, Kitt F. Petersen, Gary W. Cline, Varman T. Samuel, Gerald I. Shulman – 23 November 2012 – Genome‐wide array studies have associated the patatin‐like phospholipase domain‐containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis.

Mark A. Barnes, Megan R. McMullen, Sanjoy Roychowdhury, Sorana G. Pisano, Xiuli Liu, Abram B. Stavitsky, Richard Bucala, Laura E. Nagy – 23 November 2012 – Macrophage migration inhibitory factor (MIF), a multipotent protein that exhibits both cytokine and chemotactic properties, is expressed by many cell types, including hepatocytes and nonparenchymal cells. We hypothesized that MIF is a key contributor to liver injury after ethanol exposure.

Emerson Y. Chen, Karl Baum, William Collins, Arthur Löve, Michael Merz, Sigurdur Olafsson, Einar S. Björnsson, William M. Lee – 23 November 2012 – The patient presented below gives us the opportunity to discuss challenges in the diagnosis of drug‐induced liver injury in an era of increasing awareness of hepatitis E. (HEPATOLOGY 2012;)