Ju Hyun Shim, Han Chu Lee, Seungbong Han, Hyo Jeong Kang, Eunsil Yu, Sung‐Gyu Lee – 2 December 2012 – We retrospectively investigated the prognostic value of hepatocyte nuclear factor 1 (HNF1) proteins in 159 liver transplant patients with hepatocellular carcinoma (HCC), including 36 (22.6%) exceeding the Milan criteria. The expression of alpha‐fetoprotein (AFP), HNF1α, and HNF1β was examined with immunohistochemistry on duplicate tissue microarray slides containing HCC tumor explants.

Manav Wadhawan, Subash Gupta – 2 December 2012

Michael W. Fried, Donald M. Jensen – 29 November 2012

Håkon Haugaa, Runar Almaas, Ebbe Billmann Thorgersen, Aksel Foss, Pål Dag Line, Truls Sanengen, Gísli Björn Bergmann, Per Ohlin, Lars Wælgaard, Guro Grindheim, Soeren Erik Pischke, Tom Eirik Mollnes, Tor Inge Tønnessen – 29 November 2012 – Ischemic vascular complications and rejection occur more frequently with pediatric liver transplants versus adult liver transplants. Using intrahepatic microdialysis catheters, we measured lactate, pyruvate, glucose, and glycerol values at the bedside for a median of 10 days in 20 pediatric liver grafts.

Zhiyong Du, Cuifeng Wei, Jiqi Yan, Baosan Han, Mingjun Zhang, Chenghong Peng, Yingbin Liu – 29 November 2012 – Mesenchymal stem cell (MSC) therapy can prevent hepatic parenchymal cell loss and promote tissue repair. However, poor MSC engraftment is one of the primary barriers to the effectiveness of cell therapy because culture‐expanded MSCs progressively down‐regulate C‐X‐C chemokine receptor type 4 (CXCR4) expression and lose their ability to migrate toward a concentration gradient of stromal cell–derived factor 1a (SDF1a).

Adriana Ordóñez, Erik L. Snapp, Lu Tan, Elena Miranda, Stefan J. Marciniak, David A. Lomas – 29 November 2012 – Point mutants of alpha1‐antitrypsin (α1AT) form ordered polymers that are retained as inclusions within the endoplasmic reticulum (ER) of hepatocytes in association with neonatal hepatitis, cirrhosis, and hepatocellular carcinoma. These inclusions cause cell damage and predispose to ER stress in the absence of the classical unfolded protein response (UPR).

Catiane Tiecher Cusinato, Ana Paula Messa Koetz, Nêmora Tregnago Barcellos, Fernando Herz Wolff – 29 November 2012

Katharine Secunda, Elisa J. Gordon, Min W. Sohn, Laura A. Shinkunas, Lauris C. Kaldjian, Michael D. Voigt, Josh Levitsky – 29 November 2012 – Candidate selection for liver transplantation presents challenging ethical issues that require balancing the principles of justice and utility. The goal of this study was to assess the opinions of US transplant providers regarding the ways in which controversial medical and psychosocial characteristics influence patient eligibility for liver transplantation.

Marina Berenguer, Geoffrey McCaughan – 29 November 2012

Thomas Mone, John Heldens, Claus U. Niemann – 29 November 2012