Global epidemiology of hepatitis C virus infection: New estimates of age‐specific antibody to HCV seroprevalence

Khayriyyah Mohd Hanafiah, Justina Groeger, Abraham D. Flaxman, Steven T. Wiersma – 21 November 2012 – In efforts to inform public health decision makers, the Global Burden of Diseases, Injuries, and Risk Factors 2010 (GBD2010) Study aims to estimate the burden of disease using available parameters. This study was conducted to collect and analyze available prevalence data to be used for estimating the hepatitis C virus (HCV) burden of disease.

Influence of Age and Gender Before and After Liver Transplantation

Patrizia Burra, Eleonora De Martin, Stefano Gitto, Erica Villa – 21 November 2012 – Women constitute a particular group among patients with chronic liver disease and in the post–liver transplantation (LT) setting: they are set apart not only by traditional differences with respect to men (ie, body mass index, different etiologies of liver disease, and accessibility to transplantation) but also by factors related to hormonal changes that characterize first the fertile age and subsequently the postmenopausal period (eg, disease course variability and responses to therapy).

Self‐Reported Oral Symptoms and Signs in Liver Transplant Recipients and a Control Population

Jaana Helenius‐Hietala, Hellevi Ruokonen, Lisa Grönroos, Harri Rissanen, Liisa Suominen, Helena Isoniemi, Jukka H. Meurman – 21 November 2012 – Recipients of liver transplantation (LT) receive lifelong immunosuppression, which causes side effects. We investigated self‐reported oral symptoms and associated risk factors with the following hypothesis: symptoms and signs would differ between LT recipients of different etiology groups and also between LT recipients and a control population.

Reducing the thickness of left lateral segment grafts in neonatal living donor liver transplantation

Mureo Kasahara, Seisuke Sakamoto, Takanobu Shigeta, Hajime Uchida, Ikumi Hamano, Hiroyuki Kanazawa, Megumi Kobayashi, Toshihiro Kitajima, Akinari Fukuda, Mohamed Rela – 21 November 2012 – Liver transplantation is now an established treatment for children with end‐stage liver disease. Left lateral segment (LLS) grafts are most commonly used in split and living donor liver transplantation in children. In very small children, LLS grafts can be too large, and further nonanatomical reduction has recently been introduced to mitigate the problem of large‐for‐size grafts.

Association between plasma cyclic guanosine monophosphate levels and hemodynamic instability during liver transplantation

Dmitri Bezinover, Zakiyah Kadry, Tadahiro Uemura, Michael Sharghi, Andrea M. Mastro, Donna M. Sosnoski, Priti Dalal, Piotr K. Janicki – 16 November 2012 – The activation of cyclic guanosine monophosphate (cGMP) production in patients with end‐stage liver disease (ESLD) has been associated with hemodynamic instability during orthotopic liver transplantation (OLT). The aim of this prospective, observational study was to investigate the involvement of cGMP in the mediation of profound hypotension during liver graft reperfusion.

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