Sean R.R. Hall, Alexander Pedroza‐Gonzalez, Qiuwei Pan, Hugo W. Tilanus, Jeroen de Jonge, Gerard Wagemaker, Luc J.W. van der Laan – 30 October 2012

Austin Duffy, Julia Wilkerson, Tim F. Greten – 30 October 2012 – The presence of cirrhosis increases the potential risk of hemorrhage for patients with hepatocellular carcinoma (HCC). We evaluated the relative risk for hemorrhage in patients with HCC treated with antiangiogenic agents. We performed a systematic review and meta‐analysis of antiangiogenic studies in HCC from 1995 to 2011. For nonrandomized studies we compared bleeding risk with other HCC single‐arm studies that did not include an antiangiogenic agent.

Gyongyi Szabo, Shashi Bala – 30 October 2012

Silja Kosola, Hanna Lampela, Hannu Jalanko, Heikki Mäkisalo, Jouko Lohi, Johanna Arola, Mikko P. Pakarinen – 29 October 2012 – Controversy remains about the role of protocol liver biopsy for symptom‐free recipients and about the long‐term use of low‐dose steroids after pediatric liver transplantation (LT). We conducted a national cross‐sectional study of pediatric recipients who underwent LT between 1987 and 2007.

Shmuel Shoham – 29 October 2012

Jeffrey B. Halldorson, Harry J. Paarsch, Jennifer L. Dodge, Alberto M. Segre, Jennifer Lai, John Paul Roberts – 19 October 2012 – In the United States, livers for transplantation are distributed within donation service areas (DSAs). In DSAs with multiple transplant centers, competition among centers for organs and recipients may affect recipient selection and outcomes in comparison with DSAs with only 1 center. The objective of this study was to determine whether competition within a DSA is associated with posttransplant outcomes and variations in patients wait‐listed within the DSA.

Henrik Petrowsky, Fady Kaldas, Warwick Peacock, Dean Fisher, Johnny C. Hong, Charles Lassman, Ronald W. Busuttil – 19 October 2012

Yun Wang, Luyong Zhang, Xudong Wu, Emily C. Gurley, Elaine Kennedy, Phillip B. Hylemon, William M. Pandak, Arun J. Sanyal, Huiping Zhou – 18 October 2012 – Human immunodeficiency virus (HIV) protease inhibitors (HIV PIs) are the core components of highly active antiretroviral therapy, which has been successfully used in the treatment of HIV‐1 infection in the past two decades. However, benefits of HIV PIs are compromised by clinically important adverse effects, such as dyslipidemia, insulin resistance, and cardiovascular complications.

Jeong Kyu Kim, Ji Heon Noh, Kwang Hwa Jung, Jung Woo Eun, Hyun Jin Bae, Min Gyu Kim, Young Gyoon Chang, Qingyu Shen, Won Sang Park, Jung Young Lee, Jürgen Borlak, Suk Woo Nam – 18 October 2012 – Sirtuins are nicotinamide adenine dinucleotide oxidized form (NAD+)‐dependent deacetylases and function in cellular metabolism, stress resistance, and aging. For sirtuin7 (SIRT7), a role in ribosomal gene transcription is proposed, but its function in cancer has been unclear.

Luis Fontana, Enpeng Zhao, Muhammad Amir, Hanqing Dong, Kathryn Tanaka, Mark J. Czaja – 18 October 2012 – The prevalence of the metabolic syndrome and nonalcoholic fatty liver disease (NAFLD) in humans increases with age. It is unknown whether this association is secondary to the increased incidence of risk factors for NAFLD that occurs with aging, reflects the culmination of years of exposure to lifestyle factors such as a high‐fat diet (HFD), or results from physiological changes that characterize aging.