Incidence of colorectal cancer after liver transplantation for primary sclerosing cholangitis: A systematic review and meta‐analysis

Siddharth Singh, Jithinraj Edakkanambeth Varayil, Edward V. Loftus, Jayant A. Talwalkar – 10 September 2013 – Patients with primary sclerosing cholangitis (PSC) and associated inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We estimated the pooled incidence of CRC after liver transplantation (LT) in patients with PSC as well as in a subset of patients with associated IBD (PSC‐IBD). Through a systematic review of major bibliographic databases up to April 1, 2013, we identified cohort studies reporting the incidence of de novo CRC after LT for PSC.

Outcomes for recipients of liver transplantation for alpha‐1‐antitrypsin deficiency–related cirrhosis

Elizabeth J. Carey, Vivek N. Iyer, Darlene R. Nelson, Justin H. Nguyen, Michael J. Krowka – 10 September 2013 – Alpha‐1‐antitrypsin (AAT) deficiency is a rare genetic disease caused by an abnormal production of the serine protease inhibitor AAT. Liver transplantation (LT) cures cirrhosis caused by AAT deficiency and restores the normal production of AAT. There are few reports on the post‐LT outcomes of patients with AAT deficiency. The aim of this study was to determine the characteristics and outcomes of patients undergoing LT for AAT deficiency at 3 large transplant centers.

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