Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real‐life practice

Hua Zhang, Calvin Q. Pan, Qiumei Pang, Ruihua Tian, Miaoe Yan, Xin Liu – 27 January 2014 – Little observational data exist describing telbivudine (LdT) or lamivudine (LAM) use in late pregnancy for preventing hepatitis B mother‐to‐child transmission (MTCT) in real‐world settings. During the period of January 2009 to March 2011, we enrolled hepatitis B e antigen–positive mothers with HBV DNA >6 log10 copies/mL in China. At gestation week 28, the mothers received LdT or LAM until postpartum week 4 or no treatment (NTx). The study endpoints were the safety of LdT/LAM use and MTCT rates.

Telbivudine or lamivudine use in late pregnancy safely reduces perinatal transmission of hepatitis B virus in real‐life practice

Hua Zhang, Calvin Q. Pan, Qiumei Pang, Ruihua Tian, Miaoe Yan, Xin Liu – 27 January 2014 – Little observational data exist describing telbivudine (LdT) or lamivudine (LAM) use in late pregnancy for preventing hepatitis B mother‐to‐child transmission (MTCT) in real‐world settings. During the period of January 2009 to March 2011, we enrolled hepatitis B e antigen–positive mothers with HBV DNA >6 log10 copies/mL in China. At gestation week 28, the mothers received LdT or LAM until postpartum week 4 or no treatment (NTx). The study endpoints were the safety of LdT/LAM use and MTCT rates.

Duct‐to‐duct reconstruction in liver transplantation for primary sclerosing cholangitis is associated with fewer biliary complications in comparison with hepaticojejunostomy

Michael E. Sutton, Rico D. Bense, Ton Lisman, Eric J. Jagt, Aad P. Berg, Robert J. Porte – 24 January 2014 – There is no consensus on the preferred type of biliary reconstruction for patients undergoing orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC). The aim of this study was to compare long‐term outcomes after OLT for PSC using either duct‐to‐duct anastomosis or Roux‐en‐Y hepaticojejunostomy for biliary reconstruction.

The COP9 signalosome is a repressor of replicative stress responses and polyploidization in the regenerating liver

Martina Panattoni, Laura Maiorino, Anna Lukacs, Lorena Zentilin, Davide Mazza, Francesca Sanvito, Giovanni Sitia, Luca G. Guidotti, Ruggero Pardi – 22 January 2014 – Aberrant DNA replication induced by deregulated or excessive proliferative stimuli evokes a “replicative stress response” leading to cell cycle restriction and/or apoptosis. This robust fail‐safe mechanism is eventually bypassed by transformed cells, due to ill‐defined epistatic interactions.

Subscribe to