Rita R. Alloway, Devin E. Eckhoff, W. Kenneth Washburn, Lewis W. Teperman – 3 February 2014 – LCP‐Tacro is an extended‐release formulation of tacrolimus designed for once‐daily dosing. Studies in renal transplantation demonstrate greater bioavailability with similar safety and efficacy vs. twice‐daily tacrolimus capsules.
Kenji Takahashi, Irene Yan, Hiroaki Haga, Tushar Patel – 3 February 2014 – The identification of the presence of large RNA transcripts that do not code for proteins but that may have biological functions has provided an important new perspective in gene regulation. These long noncoding RNAs (lncRNAs) are being increasingly recognized to contribute to many biological processes through diverse mechanisms. The roles of these emerging genes are being recognized across kingdoms.
Ingrid Lua, David James, Jiaohong Wang, Kasper S. Wang, Kinji Asahina – 1 February 2014 – Hepatic stellate cells (HSCs) and portal fibroblasts (PFs) are believed to be the major source of myofibroblasts that participate in fibrogenesis by way of synthesis of proinflammatory cytokines and extracellular matrices. Previous lineage tracing studies using MesP1Cre and Rosa26lacZflox mice demonstrated that MesP1+ mesoderm gives rise to mesothelial cells (MCs), which differentiate into HSCs and PFs during liver development.
Kristopher Croome, Roberto Hernandez‐Alejandro – 31 January 2014
Michael R. Lucey – 30 January 2014
Rebecca Young, Nick Murphy, Ahmed M. Elsharkawy – 30 January 2014
Maria‐Louisa Izamis, Andreas Efstathiades, Christina Keravnou, Soteria Georgiadou, Paulo N. Martins, Michalakis A. Averkiou – 30 January 2014 – The handling of donor organs frequently introduces air into the microvasculature, but little is known about the extent of the damage caused as a function of the embolism size and distribution. Here we introduced embolisms of different sizes into the portal vein, the hepatic artery, or both during the flushing stage of porcine liver procurement.
Yongin Cho, Min Jung Lee, Eun Yeong Choe, Chang Hee Jung, Dong Jin Joo, Myoung Soo Kim, Bong Soo Cha, Joong‐Yeol Park, Eun Seok Kang – 30 January 2014 – New‐onset diabetes after transplantation (NODAT) and dyslipidemia are important metabolic complications after liver transplantation (LT) that can adversely affect both allograft and patient survival. Statins are used as first‐line therapies for dyslipidemia because of their effectiveness and safety profile. However, it has recently been reported that statin therapy is associated with new‐onset diabetes in the nontransplant population.
Enke Grabhorn, Konstantinos Tsiakas, Uta Herden, Lutz Fischer, Peter Freisinger, Thorsten Marquardt, Rainer Ganschow, Andrea Briem‐Richter, René Santer – 30 January 2014 – Deoxyguanosine kinase (DGUOK) deficiency is a well‐known cause of hepatocerebral mitochondrial DNA depletion syndromes, which include a broad spectrum of clinical presentations. Affected patients often develop life‐threatening liver failure, but the benefits of liver transplantation (LT) are controversial because of the frequently severe neurological involvement due to the underlying mitochondrial disease.
David A. Axelrod, Krista L. Lentine, Huiling Xiao, Nino Dzebisashvilli, Mark Schnitzler, Janet E. Tuttle‐Newhall, Dorry L. Segev – 30 January 2014 – Despite improved overall liver transplant outcomes, biliary complications remain a significant cause of morbidity. A national data set linking transplant registry and Medicare claims data for 17,012 liver transplant recipients was used to identify all recipients with a posttransplant biliary diagnosis code within the first 6 months after transplantation.