John W. Ward
The Task Force for Global Health
Ramesh Batra
Yale University
GI Sister Societies in Solidarity with Ukraine
The American Association for the Study of Liver Disease (AASLD), American College of Gastroenterology (ACG), American...
Statement by the AASLD Governing Board on Violence Against Asian American/ Pacific Islander Communities
As health care providers, members of the American Association for the Study of Liver Diseases (AASLD) have committed themselves...
Jonggi Choi
Asan Medical Center, University of Ulsan College of Medicine
Stavros Nicholas Stavropoulos
Archbold Medical Center
Samar H. Ibrahim
Mayo Clinic
LIVER SINUSOIDAL ENDOTHELIAL CELLS GLYCOGEN SYNTHASE KINASE 3 ACTIVATION PROMOTES LIVER INFLAMMATION AND PORTAL HYPERTENSION IN MURINE MASH
<div><p><b>Background: </b>Metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis involves both lipotoxicity (toxic lipid-induced cellular stress) and a myeloid cells-associated sterile inflammatory response. Liver sinusoidal endothelial cells (LSEC) dysfunction (impaired vasorelaxation) leading to subclinical portal hypertension in non-cirrhotic MASH is a driver of liver fibrosis. However, the role of lipotoxicity in LSEC dysfunction, and the LSEC molecular mediators of the inflammatory response in MASH are still obscure.</p>