LIVER SINUSOIDAL ENDOTHELIAL CELLS GLYCOGEN SYNTHASE KINASE 3 ACTIVATION PROMOTES LIVER INFLAMMATION AND PORTAL HYPERTENSION IN MURINE MASH

<div><p><b>Background: </b>Metabolic dysfunction-associated steatohepatitis (MASH) pathogenesis involves both lipotoxicity (toxic lipid-induced cellular stress) and a myeloid cells-associated sterile inflammatory response. Liver sinusoidal endothelial cells (LSEC) dysfunction (impaired vasorelaxation) leading to subclinical portal hypertension in non-cirrhotic MASH is a driver of liver fibrosis. However, the role of lipotoxicity in LSEC dysfunction, and the LSEC molecular mediators of the inflammatory response in MASH are still obscure.</p>

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