Clinical Pearls

Secondary Sclerosing cholangitis Sclerosing cholangitis includes a group of chronic cholestatic liver diseases characterized by inflammation and fibrosis of bile ducts, leading to the formation of...

Defining the Climate Crisis 2011-2020 was the warmest decade ever recorded. The global temperature is predicted to rise another 2.7°F by 2040 according to the Intergovernmental Panel on Climate Change...

Procedural Risk Several classifications of bleeding risk associated with invasive procedures have been proposed. High risk procedures like major surgeries, interventional endoscopic procedures...

Defining Pediatric Acute Liver Failure Pediatric acute liver failure (PALF) represents a medical emergency, characterized by the acute onset of hepatocellular damage manifesting as elevated hepatic...

Contrast-enhanced image of an acute portal vein thrombosis in a patient without cirrhosis. The asterisk denotes an area of heterogeneous enhancement due to altered perfusion and the arrow outlines the...

Introduction Wilson's disease (WD) is an inherited disorder affecting copper metabolism, resulting from homozygous or compound heterozygous mutations in the ATP7B gene. This gene encodes ATP7B, a...

Introduction The incidence of HCA was estimated to be 3-4 per 100,000 in females who use oral contraceptive pills (OCP) vs 0.13 per 100,000 in those without OCP use , based on a case-control study in...

What is Hepatitis Delta Virus? HDV is a single-stranded RNA virus that depends on the presence of Hepatitis B virus (HBV) to enter and exit hepatocytes and sustain its replication . The HDV genome...

1. Why is it important to establish liver disease severity? Patients with MASLD have increased overall mortality compared to patients without MASLD . There is growing evidence that patients with MASH...

Background: Biliary Atresia (BA) is the obstruction of bile flow due to progressive ascending destruction and obliteration of part or the entire extrahepatic biliary tree. It affects between one in 8...