Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis

Wojciech Swiatek, K. Mark Parnell, G. Allen Nickols, Bruce F. Scharschmidt, Jared Rutter – 24 March 2020 – Hyperactivation of sterol regulatory element binding protein 1c (SREBP‐1c), which transcriptionally induces expression of enzymes responsible for de novo lipogenesis and triglyceride (TG) formation, is implicated in nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) pathogenesis. Posttranslational SREBP‐1c maturation and activation is stimulated by the protein per–arnt–sim kinase (PASK).

Hepatology Highlights

Nidhi Jalan‐Sakrikar, Robert E. Schwartz, Muhammad Amir, Joel Wedd, Joseph F. Pisa, Robert S. Brown, Nicholas W. Russo, Ravi S. Vora, Alyson Kaplan, Russell Rosenblatt, Amaia Navarro‐Corcuera, Enis Kostallari, Petra Hirsova – 22 March 2020

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