Liver impairment in COVID‐19 patients: A retrospective analysis of 115 cases from a single centre in Wuhan city, China
Yafei Zhang, Liang Zheng, Lan Liu, Mengya Zhao, Jun Xiao, Qiu Zhao – 2 April 2020
The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease
Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.
The Role of Metabolic Lipases in the Pathogenesis and Management of Liver Disease
Matteo Tardelli, Francesca Virginia Bruschi, Michael Trauner – 1 April 2020 – Intracellular lipolysis is an enzymatic pathway responsible for the catabolism of triglycerides (TGs) that is complemented by lipophagy as the autophagic breakdown of lipid droplets. The hydrolytic cleavage of TGs generates free fatty acids (FFAs), which can serve as energy substrates, precursors for lipid synthesis, and mediators in cell signaling.
Issue Information
31 March 2020
Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis
Sheila Eswaran, Edie Chan – 31 March 2020
Pyruvate Dehydrogenase Kinase 4: A Key Mediator for Metabolic Regulation of Liver Regeneration
James Burdick, Zhaoli Sun – 31 March 2020
Meeting Report: The Dallas Consensus Conference on Liver Transplantation for Alcohol Associated Hepatitis
Steven Solga, Lisa Spacek – 29 March 2020
Letter to the Editor: Does Augmenter of Liver Regeneration Deficiency Pave the Way for Nonalcoholic Steatohepatitis Progression?
Thomas S. Weiss, Michael Melter, Rania Dayoub – 29 March 2020
Hepatitis B Virus RNA Profiles in Liver Biopsies by Digital Polymerase Chain Reaction
Kasthuri Prakash, Simon B. Larsson, Gustaf E. Rydell, Maria E. Andersson, Johan Ringlander, Gunnar Norkrans, Heléne Norder, Magnus Lindh – 29 March 2020 – Replication of hepatitis B virus (HBV) originates from covalently closed circular DNA (cccDNA) and involves reverse transcription of pregenomic RNA (pgRNA), which is also called core RNA and encodes the capsid protein. The RNA coding for hepatitis B surface antigen (HBsAg) in the envelope of viral or subviral particles is produced from cccDNA or from HBV DNA integrated into the host genome.
Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids
Casey A. Rimland, Samantha G. Tilson, Carola M. Morell, Rute A. Tomaz, Wei‐Yu Lu, Simone E. Adams, Nikitas Georgakopoulos, Francisco Otaizo‐Carrasquero, Timothy G. Myers, John R. Ferdinand, Richard L. Gieseck, Fotios Sampaziotis, Olivia C. Tysoe, Alexander Ross, Judith M. Kraiczy, Brandon Wesley, Daniele Muraro, Matthias Zilbauer, Gabriel C. Oniscu, Nicholas R.F. Hannan, Stuart J. Forbes, Kourosh Saeb‐Parsy, Thomas A. Wynn, Ludovic Vallier – 29 March 2020