Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene

Deepti Abbey, Susannah Elwyn, Nicholas J. Hand, Kiran Musunuru, Daniel J. Rader – 8 July 2020 – Establishment of a physiologically relevant human hepatocyte‐like cell system for in vitro translational research has been hampered by the limited availability of cell models that accurately reflect human biology and the pathophysiology of human disease. Here we report a robust, reproducible, and scalable protocol for the generation of hepatic organoids from human induced pluripotent stem cells (hiPSCs) using short exposure to nonengineered matrices.

Real‐World Effectiveness of Obeticholic Acid in Patients with Primary Biliary Cholangitis

Surain B. Roberts, Marwa Ismail, Gowthami Kanagalingam, Andrew L. Mason, Mark G. Swain, Catherine Vincent, Eric M. Yoshida, Cynthia Tsien, Jennifer A. Flemming, Harry L.A. Janssen, Gideon M. Hirschfield, Bettina E. Hansen, Aliya F. Gulamhusein, the Canadian Network for Autoimmune Liver Disease – 6 July 2020 – Patients with primary biliary cholangitis (PBC) with incomplete response to ursodeoxycholic acid are at risk of disease progression and need additional therapy.

#LiverTwitter: An Emerging Tool for Liver Education and Research

Adam E. Mikolajczyk, Nneka Ufere, Anthony C. Breu, Neehar D. Parikh, Guadalupe Garcia‐Tsao, Elliot B. Tapper – 5 July 2020 – #LiverTwitter has emerged as an academic forum that has begun to advance the field of hepatology by disseminating content on chronic liver diseases to a global audience. This article summarizes the content presented in a panel discussion at the 2019 Liver Meeting by highlighting the perspectives of several key types of participants in Twitter: the trainee, the medical educator, the divisional account, the scientific journal, and the passive participant.

Definition and Prospective Assessment of Functional Recovery After Liver Transplantation: A New Objective Consensus‐Based Metric for Safe Discharge

Raffaele Brustia, Emmanuel Boleslawski, Antoine Monsel, Louise Barbier, Sébastien Dharancy, René Adam, Jérôme Dumortier, Mickaël Lesurtel, Filomena Conti, Olivier Scatton, Groupe de Recherche Français en Greffe de Foie (GReF²) and the Association de Chirurgie Hépato‐Pancréato‐Biliaire et Transplantation (ACHBT) Collaborative Group – 4 July 2020 – Standardized discharge criteria are critical to reduce premature discharge and avoid unnecessary hospital stays. No such criteria exist for patients undergoing liver transplantation (LT).

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