Extracellular vesicles derived from mesenchymal stem/stromal cells: The regenerative impact in liver diseases

Adriana Psaraki, Lydia Ntari, Christos Karakostas, Despoina Korrou‐Karava, Maria G. Roubelakis – 26 August 2021 – Liver dysfunctions are classified into acute and chronic diseases, which comprise a heterogeneous group of pathological features and a high mortality rate. Liver transplantation remains the gold‐standard therapy for most liver diseases, with concomitant limitations related to donor organ shortage and lifelong immunosuppressive therapy.

Adjunct Fenofibrate Up‐regulates Bile Acid Glucuronidation and Improves Treatment Response For Patients With Cholestasis

Gina M. Gallucci, Jocelyn Trottier, Christopher Hemme, David N. Assis, James L. Boyer, Olivier Barbier, Nisanne S. Ghonem – 26 August 2021 – Accumulation of cytotoxic bile acids (BAs) during cholestasis can result in liver failure. Glucuronidation, a phase II metabolism pathway responsible for BA detoxification, is regulated by peroxisome proliferator–activated receptor alpha (PPARα). This study investigates the efficacy of adjunct fenofibrate therapy to up‐regulate BA‐glucuronidation and reduce serum BA toxicity during cholestasis.

Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile

Hege Marie Vedeld, Marit M. Grimsrud, Kim Andresen, Heidi D. Pharo, Erik Seth, Tom H. Karlsen, Hilde Honne, Vemund Paulsen, Martti A. Färkkilä, Annika Bergquist, Marine Jeanmougin, Lars Aabakken, Kirsten M. Boberg, Trine Folseraas, Guro E. Lind – 25 August 2021

Hepatology Highlights

Nabeel Wahid, Arun Jesudian, Adam Buckholz, Robert S. Brown, Danielle Kovac, Amani Lee, Enis Kostallari, Robert E. Schwartz, Petra Hirsova, Nidhi Jalan‐Sakrikar, Amneet Hans, Giorgio Roccaro, Alyson Kaplan, Hirsh Trivedi, Mina Choudhry, Daryl T.Y. Lau, Anthony J. Choi – 25 August 2021

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