Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice

Christian H. Holland, Ricardo O. Ramirez Flores, Maiju Myllys, Reham Hassan, Karolina Edlund, Ute Hofmann, Rosemarie Marchan, Cristina Cadenas, Jörg Reinders, Stefan Hoehme, Abdel‐latif Seddek, Steven Dooley, Verena Keitel, Patricio Godoy, Brigitte Begher‐Tibbe, Christian Trautwein, Christian Rupp, Sebastian Mueller, Thomas Longerich, Jan G. Hengstler, Julio Saez‐Rodriguez, Ahmed Ghallab – 27 August 2021 – Mouse models are frequently used to study chronic liver diseases (CLDs).

S‐adenosylmethionine inhibits la ribonucleoprotein domain family member 1 in murine liver and human liver cancer cells

Komal Ramani, Aaron E. Robinson, Joshua Berlind, Wei Fan, Aushinie Abeynayake, Aleksandra Binek, Lucía Barbier‐Torres, Mazen Noureddin, Nicholas N. Nissen, Zehra Yildirim, Ebru Erbay, José M. Mato, Jennifer E. Van Eyk, Shelly C. Lu – 26 August 2021

Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation

Nataliya Rohr‐Udilova, Kaoru Tsuchiya, Gerald Timelthaler, Martina Salzmann, Tobias Meischl, Katharina Wöran, Judith Stift, Merima Herac, Rolf Schulte‐Hermann, Markus Peck‐Radosavljevic, Wolfgang Sieghart, Robert Eferl, Erika Jensen‐Jarolim, Michael Trauner, Matthias Pinter – 26 August 2021 – Tumor‐infiltrating immune cells are relevant prognostic and immunotherapeutic targets in hepatocellular carcinoma (HCC). Mast cells play a key role in allergic response but may also be involved in anticancer immunity.

Light Chain Deposition Disease: An Unusual Cause of Portal Hypertension

Molly Delk Plummer, Fredric Regenstein – 26 August 2021 – Light chain deposition disease (LCDD) is a rare entity that is generally discovered in the setting of solid organ dysfunction. The monoclonal gammopathy leads to abnormal deposition of light chains in tissues, most often manifested by way of renal dysfunction. Other organ systems may also be affected, the liver being the second‐most common after the kidneys. Liver involvement rarely leads to clinically significant disease, with few case reports in the literature.

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