Multivariate survival analysis using Cox's regression model
Erik Christensen – 1 November 1987
Chemoimmunotherapy of experimental hepatic metastases
David L. Williams, Edward R. Sherwood, Rose B. McNamee, Ernest L. Jones, I. William Browder, Nicholas R. di Luzio – 1 November 1987 – Previous studies from our laboratory have demonstrated that particulate glucan is efficacious in the therapy of a syngeneic murine reticulum cell sarcoma (M5706), which specifically metastasizes from its primary site to the liver. The present study was undertaken to examine the therapeutic efficacy of a newly developed soluble glucan, in combination with cyclophosphamide in the treatment of hepatic metastatic disease.
Bile canalicular morphometry in arteriohepatic dysplasia
C. L. Witzleben, Milton Finegold, David A. Piccoli, William R. Treem – 1 November 1987 – The diagnosis of arteriohepatic dysplasia may be difficult, particularly in very young patients with no family history, and the pathogenesis of the disorder remains obscure. It has been reported that the typical ultrastructural changes of cholestasis are scant in this condition and proposed that there is a failure of the hepatocytes to secrete bile into the canaliculi.
Effect of colchicine and phalloidin on the distribution of three plasma membrane antigens in rat hepatocytes: Comparison with bile duct ligation
Anne‐Marie Durand‐Schneider, Michèle Maurice, Micheline Dumont, Gérard Feldmann – 1 November 1987 – The hepatocyte plasma membrane presents a morphological and functional regionalization into three domains: the sinusoidal; the lateral, and the canalicular. The mechanisms responsible for the biogenesis and maintenance of this regionalization are poorly understood. In this work, we have used colchicine and phalloidin, two drugs known to interfere with the secretory processes in hepatocytes, to study whether they also affect the transport of membrane proteins.
Foreign language hepatologic publications
Harold O. Conn – 1 November 1987
Subdivisions of idiopathic autoimmune chronic active hepatitis
Willis C. Maddrey – 1 November 1987
The role of hepatic fat‐storing (stellate) cells in retinoid metabolism
Henk F. J. Hendriks, Adriaan Brouwer, Dick L. Knook – 1 November 1987
Mucus hypersecretion in the gallbladder epithelium of ground squirrels fed a lithogenic diet for the induction of cholesterol gallstones
Ramjeet S. Pemsingh, Brian R. Macpherson, Gerald W. Scott – 1 November 1987 – This study identified mucus granules, determined mode of release and quantified their volume in the gallbladder epithelium of Richardson's ground squirrels (Spermophilus richardsonii) fed a lithogenic diet of 2% cholesterol to experimentally induce gallstone formation. Tissue was examined using light microscopy histochemistry, scanning and transmission electron microscopy, as well as autoradiography and morphometry at the electron microscopic level.
Hepatic heme synthesis in a new model of experimental hemochromatosis: Studies in rats fed finely divided elemental iron
Herbert L. Bonkovsky, John F. Healey, Beth Lincoln, Bruce R. Bacon, David F. Bishop, George H. Elder – 1 November 1987 – Rats fed chow containing finely divided elemental iron (from carbonyl‐iron) develop hepatic iron overload resembling human hereditary hemochromatosis in that deposition of iron is primarily in periportal hepatocytes and with hepatic iron concentrations sufficiently high to be associated in the human disease with hepatic fibrosis or cirrhosis.