Yasuhiro Mizoguchi, Hiroko Tsutsui, Keiji Miyajima, Yoshihide Sakagami, Shuichi Seki, Kenzo Kobayashi, Sukeo Yamamoto, Seiji Morisawa – 1 November 1987 – When a small amount of Gram‐negative lipopolysaccharide was intravenously injected into mice which had been injected with heat‐killed Propionibacterium acnes 7 days before, massive hepatic cell necrosis was induced and most of the mice died 24 hr later. However, when prostaglandin E1 was administered with lipopolysaccharide, remarkable improvements in the survival rate and in the histological changes of the liver were observed.

Y. Katsuma, S. H. H. Swierenga, U. Khettry, N. Marceau, S. W. French – 1 November 1987 – Mouse and human extracted liver tissue were examined by indirect immunofluorescent staining and transmission electron microscopy in order to study the alteration of cytokeratin intermediate filaments associated with Mallory body formation. Frozen sections of griseofulvin‐fed mouse liver and human liver of primary biliary cirrhosis and primary sclerosing cholangitis were extracted by Triton X‐100 and nuclease.

Onni Niemelä, Felix Klajner, Hector Orrego, Eva Vidins, Laurence Blendis, Yedy Israel – 1 November 1987 – Acetaldehyde, the primary metabolite of ethanol, binds covalently to proteins forming condensation products which have been recently shown to be immunogenic.

Jean‐Claude Homberg, Nisen Abuaf, Olivier Bernard, Shamsul Islam, Fernando Alvarez, Samir H. Khalil, Raoul Poupon, François Darnis, Victor‐Georges Lévy, Patrick Grippon, Pierre Opolon, Jacques Bernuau, Jean‐Pierre Benhamou, Daniel Alagille – 1 November 1987 – Sixty‐five patients with histologically proven chronic active hepatitis of unknown cause but associated with the antiliver/kidney microsome antibody type 1, confirmed by immunofluorescence and immunoprecipitation, were selected as forming a special entity.

Edward L. Krawitt, Alan E. Kilby, Richard J. Albertini, Moses S. Schanfield, Bettejayne F. Chastenay, Phillip C. Harper, Ruth M. Mickey, Timothy L. McAuliffe – 1 November 1987 – The strategy of assigning a surrogate phenotype, defined as the presence of antinuclear and/or antismooth muscle antibodies to disease‐free first degree relatives of index cases was used to search for a postulated disease susceptibility gene in autoimmune chronic active hepatitis.

Douglas Stevenson, Jiing‐Huey Lin, Myron J. Tong, G. June Marshall – 1 November 1987 – A continuous adherent cell line was established from a hepatocellular carcinoma of an HBsAg‐positive Italian male. This cell line, designated Tong/HCC, has been grown in a hormone‐supplemented medium for more than 18 months. The cell line secretes HBsAg, α‐fetoprotein, albumin and α1‐antitrypsin. α‐Fetoprotein production is enhanced by the addition of hydrocortisone and appears to be glucocorticoid concentration‐dependent.

Bernhard H. Lauterburg – 1 November 1987 – An increased influx and/or a decreased extrusion of calcium across the plasma membrane resulting in an increase in cytosolic‐free calcium could play an important role in the initiation of irreversible cell injury. Therefore, the translocation of calcium across the plasma membrane was probed in the perfused rat liver using multiple indicator dilution methodology.

Thomas C. Mahl – 1 November 1987

Mark L. Batshaw – 1 November 1987 – Twenty‐two patients with inherited hyperammonemic syndromes are presented. These patients represent 22 different families. The diagnosis was based mainly on family history, blood ammonium levels, acid base balance, urinary orotic acid, urinary and plasma amino acids and organic acids. The final diagnosis was confirmed by determination of liver enzyme activity. In 12 patients (54%), the first clinical manifestations were noticed after the neonatal period; 7 patients (31%) were diagnosed after infancy, and 8 (23%) after the age of 8 years.

Chia‐Ming Chu, Wei‐Chue Shyu, Ruey‐Wen Kuo, Yun‐Fan Liaw – 1 November 1987 – It has been suggested that cytotoxic T cells are involved in the recognition and lysis of the infected hepatocytes in chronic hepatitis B virus infection, and that the target antigen is probably HBcAg which is displayed on the hepatocyte membrane during active viral replication. However, studies in other viral infection have demonstrated that cytotoxic T cells recognize viral antigen on the infected cells only in the context of HLA class I antigens.