Chia‐Ming Chu, Wei‐Chue Shyu, Ruey‐Wen Kuo, Yun‐Fan Liaw – 1 May 1988 – It has been suggested that cytotoxic T cells are involved in the recognition and lysis of the infected hepatocytes in chronic hepatitis B virus infection, and that the target antigen is probably HBcAg which is displayed on the hepatocyte membrane during active viral replication. However, studies in other viral infection have demonstrated that cytotoxic T cells recognize viral antigen on the infected cells only in the context of HLA class I antigens.

Thierry Poynard – 1 May 1988

Paul M. Allen – 1 May 1988

Frieder Berr, Frans Stellaard, Alwin Goetz, Claus Hammer, Gustav Paumgartner – 1 May 1988 – The mechanism of ethinylestradiol‐induced biliary secretion of excess cholesterol, a potential causative factor of cholesterol gallstones, is not yet known. It might be related to altered bile acid metabolism, since the rate of cholesterol and phospholipid secreted into bile is thought to be influenced by the hydrophobicity of the bile acid species secreted.

Jacques Metzger, Srinath P. Dore, Bernhard H. Lauterburg – 1 May 1988 – Oxygen‐derived free radicals might play a role in the injury produced by reperfusion of ischemic organs. Since the generation of reactive oxygen species results in an increased formation of glutathione disulfide, we have attempted to document an oxidant stress during reperfusion of ischemic liver by following the hepatic production of glutathione disulfide in vivo and in the perfused rat liver.

Rolf Joeres, Hartwig Klinker, Hermann Heusler, Johannes Epping, Walter Zilly, Ernst Richter – 1 May 1988 – The effect of smoking on caffeine elimination was measured in 7 healthy volunteers and in 18 smoking and in 30 nonsmoking patients with alcoholic liver cirrhosis following oral application of 366 mg caffeine. In an intraindividual experiment in smoking healthy probands, caffeine clearance decreased from 118 ± 33 to 77 ± 22 ml per min (p < 0.05) after abstaining cigarette smoking for 3 weeks.

Martin Hoerner, Ursula J. Behrens, Theresa M. Worner, Ileen Blacksberg, Lawrence F. Braly, Fenton Schaffner, Charles S. Lieber – 1 May 1988 – We recently presented preliminary data indicating the presence of antibodies against acetaldehyde adducts in sera of over 70% of alcoholic patients. To assess the respective roles of liver disease and alcohol consumption as well as the specificity of this immune response, 141 patients in various stages of alcoholic and nonalcoholic liver diseases were tested by a hemagglutination assay.

M. Lombard, W. Vogel, A. Bomford, R. Williams, R. Sciot, J. J. Van Den Ord, V. J. Desmet, G. Gerken, M. Manns, G. Ramadori, K.‐H. Meyer zum Büschenfelde, I. Ghadiminejad, H. Baum, Şinasi Özsoylu – 1 May 1988

David S. Zimmon – 1 May 1988 – Original Gianturco expandable stents and their modifications were used to create an experimental intra‐hepatic portacaval anastomosis (EIPCA) in 30 young domestic swine without portal hypertension. The study focused on the design of a suitable stent, the technique of its application, the the evaluation of short‐term patency of the EIPCA. A stent with a 2.5‐cm‐long body and wire skirts on both ends was most suitable for EIPCA creation.

Pere Ginès, Wladimiro Jiménez, Vicente Arroyo, Miquel Navasa, Clara López, Llúcia Titó, Antoni Serra, Jaime Bosch, Ginès Sanz, Francisca Rivera, Joan Rodés – 1 May 1988 – The aim of this study was to determine the plasma levels, cardiac release and splanchnic extraction of atrial natriuretic factor in cirrhosis with ascites. The plasma concentration of immunoreactive atrial natriuretic factor in samples obtained from an antecubital vein was measured in 18 healthy volunteers and in 35 cirrhotics with ascites.