Kiyoshi Hasegawa, Katsumi Yamauchi, Takaji Furukawa, Hiroshi Obata – 1 September 1988 – By using dual color fluorescence analysis, peripheral T cells can be divided into four different subsets, Leu‐2a+, Leu‐2a+15−, Leu‐3a+8+ and Leu‐3a+8− cells. The ratio of these T cell subsets in hepatitis B virus‐induced hepatitis patients was studied and compared with that of controls. No significant difference was found in acute hepatitis and chronic hepatitis, but an elevation of Leu‐2a+15− (29.5 ± 2.8% vs. 18.8 ± 4.1%, p < 0.05) as well as a reduction of Leu‐2a+15+ cells (3.2 ± 0.7% vs.

Mario Chojkier, Michael Flaherty, Beverly Peterkofsky, Gopa H. Majmudar, Robert G. Spanheimer, David A. Brenner – 1 September 1988 – Weight loss is correlated with a specific decrease in collagen synthesis in extrahepatic tissues, mainly through modulation of mRNA levels. Here, we investigated the response to weight loss in the rat liver. Male rats were either fed ad libitum or fasted for 92 hr; fasted animals lost ∼20% of their initial body weight. Following i.p. injection of [5‐3H]proline, hepatic collagen was extracted and de novo collagen production was measured.

Francine Goulet, Claire Normand, Odette Morin – 1 September 1988 – Hepatocytes, prepared from normal adult rat liver, were seeded onto a collagen substratum and cultured alone or in the presence of rat liver endothelial cells. When hepatocytes were cultured alone in a hormonally defined serum‐free medium, decreased albumin production and rapid morphological deterioration of bile canaliculi structures and gap junctions occurred within 4 to 5 days.

Alberto Montanari, Isabella Simoni, Daniele Vallisa, Antonio Trifirò, Rossana Colla, Roberto Abbiati, Loris Borghi, Almerico Novarini – 1 September 1988 – Free amino acids were measured under postabsorptive conditions in plasma and intracellular water of skeletal muscle obtained by needle biopsy in nine healthy controls and 14 subjects suffering from clinically stable liver cirrhosis. The aromatic amino acids phenylalanine and tyrosine in cirrhotics were elevated to the same extent in plasma and in muscle water.

Dominique Bernuau, Anne Poliard, Gérard Feldmann – 1 September 1988 – Cellular analysis of hepatic α‐fetoprotein gene expression in normal adult rat and during regeneration induced by partial hepatectomy was performed at the cellular level by in situ hybridization using 35S‐labeled complementary DNA probes and immunoperoxidase techniques. In normal adult rat liver sections, a few α‐fetoprotein mRNA‐cDNA hybrids are detected over all hepatocytes. No protein is detected with routine immunoperoxidase methods.

Steven Schenker – 1 September 1988

1 September 1988

1 September 1988

Harold O. Conn – 1 September 1988 – An epidemiologic investigation of an acupuncturist's practice in Rhode Island identified 35 patients who were infected with hepatitis B virus during 1984. Of 366 patients seen by the acupuncturist during 1984,316 (86%) completed questionnaires and submitted serum for hepatitis B serology. Use of tests for immunoglobulin M antibody to hepatitis B core antigen (IgM anti‐HBc) identified 17 case‐patients who otherwise may have gone undetected. Thirty‐four of the 35 case‐patients were treated in only one of the two clinics run by the acupuncturist.

Charles L. Witte, Marlys H. Witte – 1 September 1988 – In a prospective study of 33 adults with portal vein thrombosis unrelated to a liver tumor, we have assessed the prevalence of primary myeloproliferative disorders using conventional criteria and cultures of bone marrow progenitor cells. A primary myeloproliferative disorder was documented in 14 patients investigated at the time of recognition of portal vein thrombosis.