1 September 1988

Eric Fréneaux, Gilles Labbe, Philippe Letteron, The Le Dinh, Claude Degott, Jean Genève, Dominique Larrey, Dominique Pessayre – 1 September 1988 – Intravenous administration of high doses of tetracycline may produce severe microvesicular steatosis of the liver in man. A similar disease is observed after ingestion of drugs which inhibit hepatic mitochondrial fatty acid β‐oxidation and in subjects with various inborn defects in this metabolic pathway. We therefore determined the effects of tetracycline on the mitochondrial oxidation of fatty acids in mice and in man.

1 September 1988

Adrian M. Di Bisceglie – 1 September 1988

Gabriel Garcia, F. Blaine Hollinger – 1 September 1988 – Hepatitis B virus (HBV) infection may induce severe hepatitis and affect long‐term survival of kidney transplant recipients. Persistent viral infection has been shown to occur despite the absence of usual serologic markers. The liver and serum HBV deoxyribonucleic acid (DNA) status of 90 patients were studied prospectively; recently transplanted patients, both hepatitis B virus surface antigen (HBsAg)‐positive and negative, with and without liver disease, were investigated with HBV serology, serum HBV DNA, and liver histology.

Jay H. Lefkowitch – 1 September 1988 – Five cases of ovarian carcinoma with hepatoid features, three of them primary and two probably primary, are described. The tumor cells were arranged predominantly in sheets and contained moderate to abundant amounts of eosinophilic cytoplasm; varying numbers of tumor cells stained immunohistochemically for alpha‐fetoprotein.

Jacquelyn J. Maher – 1 September 1988

S. C. Arya – 1 September 1988

William C. Duane, Donald B. Hunninghake, Martin L. Freeman, Pete A. Pooler, Linda A. Schlasner, Roger L. Gebhard – 1 September 1988 – We tested the possibility that simvastatin, a competitive inhibitor of HMG‐CoA reductase related to mevinolin, might alter cholesterol saturation of gallbladder bile. Ten patients with Type IIa or IIb hypercholesterolemia underwent bile sampling before, and again after, treatment with 20 or 40 mg per day simvastatin for 7 to 13 weeks. Mean cholesterol saturation index of gallbladder bile fell from 1.01 to 0.77 during simvastatin treatment (p < 0.01).

Hanna Shalev‐Zimels, Zvi Weizman, Chaim Lotan, Dov Gavish, Zvi Ackerman, Abraham Morag – 1 September 1988 – To assess extent of hepatic involvement in measles, we evaluated prospectively 144 patients (ages 0.2 to 43 years) during an outbreak. Liver function parameters (AST, ALT, serum γ‐glutamyl transpeptidase and bilirubin) were determined on presentation and at 2 and 4 weeks.