John C. Hoefs, Felix Wang, Gary Kanel, Philip Braunstein – 1 October 1995 – Sulfur colloid distribution on liver‐spleen scan is determined by the perfused Kupffer cell mass. The perfused Kupffer cell mass is proportional to the perfused hepatocyte mass, but is less affected by acute changes in hepatocyte function. Thus, sulfur colloid distribution parameters (precisely measured by quantitative liver‐spleen scan [QLSS]) may be an excellent test of the perfused hepatic mass.

Raymond S. Koff – 1 October 1995

Raymond S. Koff – 1 October 1995

Howard N. Sankary, Anita Chong, Preston Foster, Esther Brown, Jikun Shen, Robert Kimura, Guarimella Rayudu, James Williams – 1 October 1995 – Data from recent studies suggest that donor fasting imparts a beneficial effect on the viability of transplanted hepatic allografts. Because starvation may temporarily inactivate Kupffer cells, and because these cells are the likely mediators of liver injury after prolonged preservation‐reperfusion, the purpose of this study is to establish a link between improved organ viability and Kupffer cell inactivation caused by donor allograft fasting.

Rudolf A. Heijtink, Johannes Kruining, Yvonne A. M. Weber, Robert A. de Man, Solko W. Schalm – 1 October 1995 – Two human monoclonal antibodies with anti‐hepatitis B activity were investigated separately and as a mixture by means of an “inhibition in solution” assay. With this assay the capacity of anti‐HBs antibodies to inhibit the binding of hepatitis B surface antigen (HBsAg) with solid‐phase anti‐HBs (Ausria II, Abbott Laboratories) was studied. Both HBsAg of different subtypes and purified Dane particles were used.

Thomas Leitha, Anton Staudenherz, Marcela Hermann, Manfred Hüttinger, Bernhard Gmeiner – 1 October 1995 – This study quantifies the parenchymal and nonparen‐chymal uptake of technetium‐99m (99mTc)‐ and indium‐III (111In)‐low‐density lipoprotein (LDL) in different states of hepatic LDL‐receptor activity to validate quantitative LDL scintigraphy. Iodine‐125 (125I)‐LDL was used as reference tracer.

Onni Nlemelä, Seppo Parkkila, Seppo Ylä‐herttuala, Jesus Villanueva, Boris Ruebner, Charles H. Halsted – 1 October 1995 – The pathogenesis of alcohol‐induced liver disease involves the adverse effects of ethanol metabolites and oxidative tissue injury. Previous studies indicated that covalent protein adducts with reactive aldehydes may be formed in alcohol consumers.

Alain Rolachon, Laurent Cordier, Yannick Bacq, Jean‐Baptiste Nousbaum, Anne Franza, Jean‐Claude Paris, Serge Fratte, Benoit Bohn, Pascal Kitmacher, Jean‐Paul Stahl, Jean‐Pierre Zarski – 1 October 1995 – The aim of this prospective double‐blind study was to evaluate the value of long‐term antibiotic prophylaxis using ciprofloxacin for the prevention of spontaneous bacterial peritonitis (SBP) in 60 cirrhotic patients with low ascitic fluid protein levels (<15 g/L).

Massimo Siciliano, Daniele Tomasello, Alessandro Milani, Bianca Maria Ricerca, Sergio Storti, Lodovico Rossi – 1 October 1995 – Chronic anemia is frequently observed in patients affected by cirrhosis. To investigate the possible role of erythropoietin (Epo) in the pathogenesis of anemia in cirrhosis, we measured the immunoreactive Epo levels and the respective hemoglobin (Hb) concentrations in 48 anemic and nonanemic cirrhotic patients and in a control group of healthy subjects and patients with iron‐deficiency anemia.

Shirley Coverdale, Karen Byth, Jacqueline Field, Christopher Liddle, Rita Lin, Geoffrey C. Farrell – 1 October 1995 – To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome.