Hepatic distribution of E2 component of pyruvate dehydrogenase complex after transplantation

James Neuberger, Lorraine Wallace, Ruth Joplin, Stefan Hubscher – 1 September 1995 – We have examined the distribution of the E2 component of pyruvate dehydrogenase complex in the liver of patients with native primary biliary cirrhosis (PBC), and after transplantation, using affinity‐purified anti‐E2 antibodies. In the posttransplantation group, we studied biopsy specimens from patients grafted for conditions other than PBC (n = 6) and those grafted for PBC with (n = 6) and without (n = 5) histological features suggestive of PBC recurrence.

Randomized trial comparing three different regimens of alpha‐2a‐interferon in chronic hepatitis C

Liliana Chemello, Paola Bonetti, Luisa Cavalletto, Fabiola Talato, Valter Donadon, Pietro Casarin, Fabio Belussi, Mario Frezza, Franco Noventa, Patrizia Pontisso, Luisa Benvegnù, Carla Casarin, Alfredo Alberti, The TriVeneto Viral Hepatitis Group – 1 September 1995 – Alpha‐interferon (IFN‐α) is an effective treatment for chronic hepatitis C, but only 20% to 30% of patients are apparently cured with the currently recommended schedule of 3 MU given three times a week for 6 months.

In vitro activation of woodchuck lymphocytes measured by radiopurine incorporation and interleukin‐2 production: Implications for modeling immunity and therapy in hepatitis B virus infection

Paul J. Cote, John L. Gerin – 1 September 1995 – Cellular immune responses to hepatitis B virus (HBV) play an important role in the resolution of acute infection. They also influence the course of chronic infection and disease but are inadequate to completely clear the infection. Woodchuck hepatitis virus (WHV) infection of the woodchuck can provide a model to study these processes.

Liver transplantation and the alcoholic patient:Medical, surgical, and psychosocial issues by Michael R. Lucey, Michael R. Lucey, Robert M. Marian, Thomas P. Beresford. 134 pp. New York, NY: Cambridge University Press, 1994 $49.95

Organellar clusters formed by mitochondrial‐rough endoplasmic reticulum associations: An ordered arrangement of mitochondria in hepatocytes

Joseph Cascarano, Patricia A. Chambers, Eileen Schwartz, Parvoneh Poorkaj, Roy E. Gondo – 1 September 1995 – Our objective was to determine if mitochondrial‐rough endoplasmic reticulum (mt‐RER) associations provide for an ordered arrangement of mitochondria in the cell. If such an ordered arrangement exists, it might be manifested by grouping of mitochondria according to size and biochemical properties. Liver homogenate was subjected to rate zonal centrifugation for fractionating mitochondrial clusters. These clusters were then examined for morphological and biochemical characteristics.

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