Intestinal virome in patients with alcohol use disorder and after abstinence

Cynthia L. Hsu, Xinlian Zhang, Lu Jiang, Sonja Lang, Phillipp Hartmann, David Pride, Derrick E. Fouts, Peter Stärkel, Bernd Schnabl – 1 April 2022 – Alcohol use is a leading cause of chronic liver disease worldwide, and changes in the microbiome associated with alcohol use contribute to patients’ risk for liver disease progression. Less is known about the effects of alcohol use on the intestinal viral microbiome (virome) and interactions between bacteriophages and their target bacteria.

HBsAg isoform dynamics during NAP‐based therapy of HBeAg‐negative chronic HBV and HBV/HDV infection

Michel Bazinet, Mark Anderson, Victor Pântea, Gheorghe Placinta, Iurie Moscalu, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Liviu Iarovoi, Valentina Smesnoi, Tatina Musteata, Alina Jucov, Ulf Dittmer, Jeff Gersch, Vera Holzmayer, Mary Kuhns, Gavin Cloherty, Andrew Vaillant – 1 April 2022 – Nucleic acid polymers block the assembly of hepatitis B virus (HBV) subviral particles, effectively preventing hepatitis B surface antigen (HBsAg) replenishment in the circulation.

Predicting NAFLD prevalence in the United States using National Health and Nutrition Examination Survey 2017–2018 transient elastography data and application of machine learning

Mazen Noureddin, Fady Ntanios, Deepa Malhotra, Katherine Hoover, Birol Emir, Euan McLeod, Naim Alkhouri – 31 March 2022 – This cohort analysis investigated the prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD with fibrosis at different stages, associated clinical characteristics, and comorbidities in the general United States population and a subpopulation with type 2 diabetes mellitus (T2DM), using the National Health and Nutrition Examination Survey (NHANES) database (2017–2018).

Src homology 3 domain binding kinase 1 protects against hepatic steatosis and insulin resistance through the Nur77–FGF21 pathway

Palak Ahuja, Xinyi Bi, Chun Fai Ng, Margaret Chui Ling Tse, Miaojia Hang, Brian Pak Shing Pang, Elsie Chit Yu Iu, Wing Suen Chan, Xin Ci Ooi, Anqi Sun, Oana Herlea‐Pana, Zhixue Liu, Xiuying Yang, Baowei Jiao, Xin Ma, Kelvin Ka Lok Wu, Leo Tsz On Lee, Kenneth King Yip Cheng, Chi Wai Lee, Chi Bun Chan – 31 March 2022

LKB1 acts as a critical brake for the glucagon‐mediated fasting response

Suehelay Acevedo‐Acevedo, Megan L. Stefkovich, Sun Woo Sophie Kang, Rory P. Cunningham, Constance M. Cultraro, Natalie Porat‐Shliom – 30 March 2022 – As important as the fasting response is for survival, an inability to shut it down once nutrients become available can lead to exacerbated disease and severe wasting. The liver is central to transitions between feeding and fasting states, with glucagon being a key initiator of the hepatic fasting response. However, the precise mechanisms controlling fasting are not well defined.

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