Abnormal liver tests are not sufficient for diagnosis of hepatic graft‐versus‐host disease in critically ill patients

Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller – 8 May 2022 – Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific.

Caregiver perspectives on the everyday medical and social needs of long‐term pediatric liver transplant patients

Sharad I. Wadhwani, Ana‐Gabriela Barrera, Holly P. Shifman, Ethel Baker, John Bucuvalas, Lara M. Gottlieb, Uma Kotagal, Sue J. Rhee, Jennifer C. Lai, Courtney R. Lyles – 6 May 2022 – Using in‐depth interviews, we sought to characterize the everyday medical and social needs of pediatric liver transplant caregivers to inform the future design of solutions to improve care processes. Participants (parents/caregivers of pediatric liver transplant recipients) completed a survey (assessing socioeconomic status, economic hardship, health literacy, and social isolation).

Endoplasmic reticulum stress in liver diseases

Amir Ajoolabady, Neil Kaplowitz, Cynthia Lebeaupin, Guido Kroemer, Randal J. Kaufman, Harmeet Malhi, Jun Ren – 5 May 2022 – The endoplasmic reticulum (ER) is an intracellular organelle that fosters the correct folding of linear polypeptides and proteins, a process tightly governed by the ER‐resident enzymes and chaperones. Failure to shape the proper 3‐dimensional architecture of proteins culminates in the accumulation of misfolded or unfolded proteins within the ER, disturbs ER homeostasis, and leads to canonically defined ER stress.

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