Pediatric acute liver failure: Reexamining key clinical features, current management, and research prospects

Johanna M. Ascher Bartlett, George Yanni, Yong Kwon, Juliet Emamaullee – 11 May 2022 – This review aims to synthesize the most updated research, outcomes, and trends in the field of pediatric liver transplantation (LT), specifically focusing on children who have suffered from acute liver failure. Pediatric acute liver failure is a dynamic, life‐threatening condition that can either self‐resolve or lead to death. LT is a lifesaving intervention.

Factors associated with improved patient and graft survival beyond 1 year in pediatric liver transplantation

James E. Squires, Jacob Bilhartz, Kyle Soltys, Einar Hafberg, George V. Mazariegos, Nitika A. Gupta, Ravinder Anand, Sarah G. Anderson, Tamir Miloh, for the Society of Pediatric Liver Transplantation – 11 May 2022 – With advances in surgical techniques, medical management, and more equitable allocation systems, children who receive a liver transplantation (LT) today can expect remarkable outcomes early after LT. However, beyond 1 year after transplant, attrition rates have not improved. We reviewed two separate eras (Era 1: January 1995–June 2004 vs.

Location and allocation: Inequity of access to liver transplantation for patients with severe acute‐on‐chronic liver failure in Europe

Thierry Artzner, William Bernal, Luca S. Belli, Sara Conti, Paolo A. Cortesi, Sophie‐Caroline Sacleux, George‐Philippe Pageaux, Sylvie Radenne, Jonel Trebicka, Javier Fernandez, Giovanni Perricone, Salvatore Piano, Silvio Nadalin, Maria C. Morelli, Silvia Martini, Wojciech G. Polak, Krzysztof Zieniewicz, Christian Toso, Marina Berenguer, Claudia Iegri, Federica Invernizzi, Riccardo Volpes, Vincent Karam, René Adam, François Faitot, Liane Rabinowich, Faouzi Saliba, Lucy Meunier, Mickael Lesurtel, Frank E.

Patterns of kidney dysfunction in acute‐on‐chronic liver failure: Relationship with kidney and patients’ outcome

Laura Napoleone, Cristina Solé, Adrià Juanola, Ann T. Ma, Marta Carol, Martina Pérez‐Guasch, Ana‐Belén Rubio, Marta Cervera, Emma Avitabile, Octavi Bassegoda, Jordi Gratacós‐Ginès, Manuel Morales‐Ruiz, Núria Fabrellas, Isabel Graupera, Elisa Pose, Gonzalo Crespo, Elsa Solà, Pere Ginès – 9 May 2022 – Impairment of kidney function is common in acute‐on‐chronic liver failure (ACLF). Patterns of kidney dysfunction and their impact on kidney and patient outcomes are ill‐defined.

Abnormal liver tests are not sufficient for diagnosis of hepatic graft‐versus‐host disease in critically ill patients

Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller – 8 May 2022 – Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific.

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