Ethanol‐induced cytochrome P4502E1 causes carcinogenic etheno‐DNA lesions in alcoholic liver disease

Ying Wang, Gunda Millonig, Jagadeesan Nair, Eleonora Patsenker, Felix Stickel, Sebastian Mueller, Helmut Bartsch, Helmut K. Seitz – 29 July 2009 – Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), a frequent complication of alcoholic liver disease (ALD). However, the underlying mechanisms are poorly understood.

The influence of the explant technique on the hemodynamic profile during sequential domino liver transplantation in familial amyloid polyneuropathy patients

Bibiana Escobar, Pilar Taura, Nelson Barreneche, Joan Beltran, Jaume Balust, Graciela Martinez‐Palli, Elizabeth Zavala, Angels Escorsell, Juan Carlos Garcia‐Valdecasas – 29 July 2009 – Familial amyloidotic polyneuropathy (FAP) patients present adrenergic cardiac input blockade secondary to amyloid deposits and sympathetic neuropathy. Consequently, their capacity to compensate for hemodynamic changes is limited. To avoid hemodynamic disturbances in sequential liver transplants, a standard procedure with venovenous bypass or inferior vena cava preservation is contemplated.

Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience

Paulette Bioulac‐Sage, Hervé Laumonier, Gabrielle Couchy, Brigitte Le Bail, Antonio Sa Cunha, Anne Rullier, Christophe Laurent, Jean‐Frédéric Blanc, Gaelle Cubel, Hervé Trillaud, Jessica Zucman‐Rossi, Charles Balabaud, Jean Saric – 29 July 2009 – We took advantage of the reported genotype/phenotype classification to analyze our surgical series of hepatocellular adenoma (HCA). The series without specific known etiologies included 128 cases (116 women). The number of nodules varies from single, <5, and ≥5 in 78, 38, and 12 cases, respectively. The resection was complete in 95 cases.

Identification of microRNA‐181 by genome‐wide screening as a critical player in EpCAM–positive hepatic cancer stem cells

Junfang Ji, Taro Yamashita, Anuradha Budhu, Marshonna Forgues, Hu‐Liang Jia, Cuiling Li, Chuxia Deng, Elaine Wauthier, Lola M. Reid, Qing‐Hai Ye, Lun‐Xiu Qin, Wen Yang, Hong‐Yang Wang, Zhao‐You Tang, Carlo M. Croce, Xin Wei Wang – 29 July 2009 – MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it is heterogeneous in clinical outcomes and biological activities.

Antifungal prophylaxis in liver transplant recipients

Gregory A. Eschenauer, Simon W. Lam, Peggy L. Carver – 29 July 2009 – Although the overall incidence of fungal infections in liver transplant recipients has declined, these infections still contribute significantly to the morbidity and mortality of patients with risk factors for infection. Although antifungal prophylaxis has been widely studied and practiced, no consensus exists on which patients should receive prophylaxis, with which agent, and for what duration.

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